Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064472-02
Application #
2106966
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1995-04-01
Project End
1998-03-31
Budget Start
1996-04-15
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Georgetown University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
MacCarthy, Caitlin M; Notario, Vicente (2013) The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family. Int J Oncol 43:1244-52
Liu, Y; Yan, S; Wondimu, A et al. (2010) Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth. Oncogene 29:3297-306
Villar, JoaquĆ­n; Quadri, Humair S; Song, Insun et al. (2009) PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization. Cancer Res 69:102-10
Becerra, S Patricia; Perez-Mediavilla, L Alberto; Weldon, John E et al. (2008) Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site. J Biol Chem 283:33310-20
Villar, Joaquin; Arenas, Maria Isabel; MacCarthy, Caitlin M et al. (2007) PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. Cancer Res 67:10859-68
Tirado, Oscar M; Mateo-Lozano, Silvia; Sanders, Sean et al. (2003) The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation. Cancer Res 63:6290-8
Solanas, Montserrat; Escrich, Eduard; Rouzaut, Ana et al. (2002) Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene. Mol Carcinog 33:219-27
Blanquez, Maria Jose; Regadera, Javier; Marino, Javier et al. (2002) Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia. Mol Carcinog 35:186-95
Soldatenkov, Viatcheslav A; Trofimova, Irina N; Rouzaut, Ana et al. (2002) Differential regulation of the response to DNA damage in Ewing's sarcoma cells by ETS1 and EWS/FLI-1. Oncogene 21:2890-5
Recio, Juan A; Paez, J Guillermo; Sanders, Sean et al. (2002) Partial depletion of intracellular ATP mediates the stress-survival function of the PCPH oncoprotein. Cancer Res 62:2690-4

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