Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064585-02
Application #
2107160
Study Section
Radiation Study Section (RAD)
Project Start
1995-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Day, Tovah A; Layer, Jacob V; Cleary, J Patrick et al. (2017) PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun 8:15110
Gursoy-Yuzugullu, Ozge; Carman, Chelsea; Price, Brendan D (2017) Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair. Sci Rep 7:12921
Dhar, Surbhi; Gursoy-Yuzugullu, Ozge; Parasuram, Ramya et al. (2017) The tale of a tail: histone H4 acetylation and the repair of DNA breaks. Philos Trans R Soc Lond B Biol Sci 372:
Price, Brendan D (2017) KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks. J Cell Biol 216:1871-1873
Ströbel, Thomas; Madlener, Sibylle; Tuna, Serkan et al. (2017) Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma. Sci Rep 7:9674
Gursoy-Yuzugullu, Ozge; Carman, Chelsea; Serafim, Rodolfo Bortolozo et al. (2017) Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity. Oncotarget 8:24518-24532
Gursoy-Yuzugullu, Ozge; House, Nealia; Price, Brendan D (2016) Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks. J Mol Biol 428:1846-60
Gursoy-Yuzugullu, Ozge; Ayrapetov, Marina K; Price, Brendan D (2015) Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair. Proc Natl Acad Sci U S A 112:7507-12
Du, Fengxia; Zhang, Minjie; Li, Xiaohua et al. (2014) Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun 452:1034-9
Ayrapetov, Marina K; Gursoy-Yuzugullu, Ozge; Xu, Chang et al. (2014) DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc Natl Acad Sci U S A 111:9169-74

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