Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA066163-02
Application #
2109424
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1995-04-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Bourguignon, Lilly Y W; Earle, Christine; Shiina, Marisa (2017) Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells. Int J Mol Sci 18:
Bourguignon, Lilly Y W; Wong, Gabriel; Shiina, Marisa (2016) Up-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma. J Biol Chem 291:10571-85
Bourguignon, Lilly Y W (2016) Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression. Int J Mol Sci 17:517
Bourguignon, Lilly Y W; Bikle, Daniel (2015) Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol 6:224
Shiina, Marisa; Bourguignon, Lilly Y W (2015) Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer. Int J Cell Biol 2015:989070
Hurst, Robert E; Hauser, Paul J; You, Youngjae et al. (2015) Identification of novel drugs to target dormant micrometastases. BMC Cancer 15:404
Bourguignon, Lilly Y W; Shiina, Marisa; Li, Jian-Jian (2014) Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression. Adv Cancer Res 123:255-75
Chan, John K; Blansit, Kevin; Kiet, Tuyen et al. (2014) The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer. Gynecol Oncol 132:739-44
Chen, Liqun; Bourguignon, Lilly Y W (2014) Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells. Mol Cancer 13:52
Bourguignon, Lilly Y W (2014) Matrix hyaluronan-activated CD44 signaling promotes keratinocyte activities and improves abnormal epidermal functions. Am J Pathol 184:1912-9

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