Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA067358-02
Application #
2111022
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1995-03-15
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Marin, Mariana; Golem, Sheetal; Kozak, Susan L et al. (2016) Movements of HIV-1 genomic RNA-APOBEC3F complexes and PKR reveal cytoplasmic and nuclear PKR defenses and HIV-1 evasion strategies. Virus Res 213:124-139
Platt, Emily J; Durnin, James P; Kabat, David (2015) Short Communication: HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120's V3 Crown with CCR5 Extracellular Loop 1. AIDS Res Hum Retroviruses 31:992-8
Platt, Emily J; Gomes, Michelle M; Kabat, David (2014) Reversible and efficient activation of HIV-1 cell entry by a tyrosine-sulfated peptide dissects endocytic entry and inhibitor mechanisms. J Virol 88:4304-18
López, Claudia S; Sloan, Rachel; Cylinder, Isabel et al. (2014) RRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release. Virology 462-463:126-34
Platt, Emily J; Gomes, Michelle M; Kabat, David (2012) Kinetic mechanism for HIV-1 neutralization by antibody 2G12 entails reversible glycan binding that slows cell entry. Proc Natl Acad Sci U S A 109:7829-34
Platt, Emily J; Kozak, Susan L; Durnin, James P et al. (2010) Rapid dissociation of HIV-1 from cultured cells severely limits infectivity assays, causes the inactivation ascribed to entry inhibitors, and masks the inherently high level of infectivity of virions. J Virol 84:3106-10
Platt, Emily J; Bilska, Miroslawa; Kozak, Susan L et al. (2009) Evidence that ecotropic murine leukemia virus contamination in TZM-bl cells does not affect the outcome of neutralizing antibody assays with human immunodeficiency virus type 1. J Virol 83:8289-92
Platt, Emily J; Durnin, James P; Shinde, Ujwal et al. (2007) An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations. J Mol Biol 374:64-79
Melikyan, Gregory B; Platt, Emily J; Kabat, David (2007) The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment. Retrovirology 4:55
Platt, Emily J; Durnin, James P; Kabat, David (2005) Kinetic factors control efficiencies of cell entry, efficacies of entry inhibitors, and mechanisms of adaptation of human immunodeficiency virus. J Virol 79:4347-56

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