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Obayashi, Eiji; Luna, Rafael E; Nagata, Takashi et al. (2017) Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep 18:2651-2663
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Salvi, Nicola; Papadopoulos, Evangelos; Blackledge, Martin et al. (2016) The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex. Angew Chem Int Ed Engl 55:7176-9
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Edmonds, Katherine A; Wagner, Gerhard (2015) (1)H, (13)C, and (15)N backbone and sidechain chemical shift assignments for the HEAT2 domain of human eIF4GI. Biomol NMR Assign 9:157-60
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Sekiyama, Naotaka; Arthanari, Haribabu; Papadopoulos, Evangelos et al. (2015) Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A 112:E4036-45
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Yi, Tingfang; Arthanari, Haribabu; Akabayov, Barak et al. (2015) eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun 6:7194
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Leigh, Kendra E; Sharma, Mayuri; Mansueto, My Sam et al. (2015) Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A 112:9010-5
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Mahalingam, Poornachandran; Takrouri, Khuloud; Chen, Ting et al. (2014) Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem 57:5094-111
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Yefidoff-Freedman, Revital; Chen, Ting; Sahoo, Rupam et al. (2014) 3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction. Chembiochem 15:595-611
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Luna, Rafael E; Akabayov, Sabine R; Ziarek, Joshua J et al. (2014) Examining weak protein-protein interactions in start codon recognition via NMR spectroscopy. FEBS J 281:1965-73
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Martin-Marcos, Pilar; Nanda, Jagpreet S; Luna, Rafael E et al. (2014) Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. RNA 20:150-67
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