Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA068471-02
Application #
2112445
Study Section
Experimental Immunology Study Section (EI)
Project Start
1995-08-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Harhaj, Nicole S; Sun, Shao-Cong; Harhaj, Edward W (2007) Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem 282:4185-92
Wu, Xuefeng; Sun, Shao-Cong (2007) Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. EMBO Rep 8:510-5
Babu, Geetha; Waterfield, Michael; Chang, Mikyoung et al. (2006) Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem 281:14041-7
Harhaj, Edward W; Harhaj, Nicole S; Grant, Christian et al. (2005) Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology 333:145-58
Sun, Shao-Cong; Yamaoka, Shoji (2005) Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 24:5952-64
Cvijic, Mary Ellen; Xiao, Gutian; Sun, Shao-Cong (2003) Study of T-cell signaling by somatic cell mutagenesis and complementation cloning. J Immunol Methods 278:293-304
Sun, Shao-Cong; Xiao, Gutian (2003) Deregulation of NF-kappaB and its upstream kinases in cancer. Cancer Metastasis Rev 22:405-22
Waterfield, Michael R; Zhang, Minying; Norman, Lourdes P et al. (2003) NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell 11:685-94
Xiao, G; Cvijic, M E; Fong, A et al. (2001) Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 20:6805-15
Rivera-Walsh, I; Waterfield, M; Xiao, G et al. (2001) NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J Biol Chem 276:40385-8

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