Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA070329-01
Application #
2114238
Study Section
Special Emphasis Panel (ZRG3-BNP (01))
Project Start
1996-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Smith 3rd, Amos B; Risatti, Christina A; Atasoylu, Onur et al. (2011) Design, synthesis, and biological evaluation of diminutive forms of (+)-spongistatin 1: lessons learned. J Am Chem Soc 133:14042-53
Xu, Qunli; Huang, Kuan-Chun; Tendyke, Karen et al. (2011) In vitro and in vivo anticancer activity of (+)-spongistatin 1. Anticancer Res 31:2773-9
Atasoylu, Onur; Furst, George; Risatti, Christina et al. (2010) The solution structure of (+)-spongistatin 1 in DMSO. Org Lett 12:1788-91
Smith 3rd, Amos B; Risatti, Christina A; Atasoylu, Onur et al. (2010) Design, synthesis, and biological evaluation of EF- and ABEF- analogues of (+)-spongistatin 1. Org Lett 12:1792-5
Smith, Amos B; Lin, Qiyan; Doughty, Victoria A et al. (2009) Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2. Tetrahedron 65:6470-6488
Smith, Amos B; Sfouggatakis, Chris; Risatti, Christina A et al. (2009) Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1. Tetrahedron 65:6489-6509
Smith 3rd, Amos B; Tomioka, Takashi; Risatti, Christina A et al. (2008) Gram-scale synthesis of (+)-spongistatin 1: development of an improved, scalable synthesis of the F-ring subunit, fragment union, and final elaboration. Org Lett 10:4359-62
Smith 3rd, Amos B; Fox, Richard J; Razler, Thomas M (2008) Evolution of the Petasis-Ferrier union/rearrangement tactic: construction of architecturally complex natural products possessing the ubiquitous cis-2,6-substituted tetrahydropyran structural element. Acc Chem Res 41:675-87
Smith 3rd, Amos B; Sfouggatakis, Chris; Gotchev, Dimitar B et al. (2004) Spongistatin synthetic studies. evolution of a scalable synthesis for the EF fragment of (+)-Spongistatin 1 exploiting a Petasis-Ferrier union/rearrangement tactic. Org Lett 6:3637-40
Smith 3rd, Amos B; Adams, Christopher M (2004) Evolution of dithiane-based strategies for the construction of architecturally complex natural products. Acc Chem Res 37:365-77

Showing the most recent 10 out of 16 publications