Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA071387-08
Application #
6513012
Study Section
Radiation Study Section (RAD)
Program Officer
Pelroy, Richard
Project Start
1996-08-15
Project End
2004-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
8
Fiscal Year
2002
Total Cost
$374,792
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Goldstein, Michael; Kastan, Michael B (2015) Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res 75:2699-707
Goldstein, Michael; Derheimer, Frederick A; Tait-Mulder, Jacqueline et al. (2013) Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. Proc Natl Acad Sci U S A 110:16874-9
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Derheimer, Frederick A; Kastan, Michael B (2010) Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett 584:3675-81
Alexander, Angela; Cai, Sheng-Li; Kim, Jinhee et al. (2010) ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 107:4153-8
Rainey, Michael D; Charlton, Maura E; Stanton, Robert V et al. (2008) Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res 68:7466-74
Tang, Xi; Hui, Zhou-Guang; Cui, Xiao-Li et al. (2008) A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. Mol Cell Biol 28:2559-66
Maclean, Kirsteen H; Dorsey, Frank C; Cleveland, John L et al. (2008) Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118:79-88
Berkovich, Elijahu; Monnat Jr, Raymond J; Kastan, Michael B (2008) Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites. Nat Protoc 3:915-22

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