Ras family GTPases are critical components of cell regulatory systems that control proliferation, differentiation, and cell survival. Inappropriate regulation of these systems directly contributes to initiation and progression of human cancer. This proposal is directed at increasing our understanding of the composition, organization, and function of cell regulatory networks engaged by Ras family GTPases. Our focus is on the dominant effector pathways that mediate oncogenic Ras-induced cell transformation.
Our specific aims are 1) revealing the molecular basis of the contribution of Ral GTPases to support of human tumor cell proliferation and survival; 2) assessing the role of two candidate Ras effectors in limiting cellular responses to mitogenic signals; and 3) defining the contribution of scaffolding proteins to the generation of signal fidelity on the ERK1/2 MAP kinase cascade..
| Cooper, Jonathan M; Ou, Yi-Hung; McMillan, Elizabeth A et al. (2017) TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. Cancer Res 77:5077-5094 |
| Wang, Chensu; Niederstrasser, Hanspeter; Douglas, Peter M et al. (2017) Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun 8:2270 |
| Eskiocak, Banu; McMillan, Elizabeth A; Mendiratta, Saurabh et al. (2017) Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma. Cancer Discov 7:832-851 |
| Wang, Chensu; Zhao, Tian; Li, Yang et al. (2017) Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes. Adv Drug Deliv Rev 113:87-96 |
| Thomas, Jemima C; Cooper, Jonathan M; Clayton, Natasha S et al. (2016) Inhibition of Ral GTPases Using a Stapled Peptide Approach. J Biol Chem 291:18310-25 |
| Fisher, Kurt W; Das, Binita; Kim, Hyun Seok et al. (2015) AMPK Promotes Aberrant PGC1? Expression To Support Human Colon Tumor Cell Survival. Mol Cell Biol 35:3866-79 |
| Pineda, Carlos T; Ramanathan, Saumya; Fon Tacer, Klementina et al. (2015) Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell 160:715-728 |
| Borkowski, Robert; Du, Liqin; Zhao, Zhenze et al. (2015) Genetic mutation of p53 and suppression of the miR-17?92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D Signaling. Cancer Res 75:666-75 |
| Potts, Malia B; McMillan, Elizabeth A; Rosales, Tracy I et al. (2015) Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B. Nat Chem Biol 11:401-8 |
| Torres, Michael J; Pandita, Raj K; Kulak, Ozlem et al. (2015) Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol 35:3633-45 |
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