Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA072433-02
Application #
2692056
Study Section
Experimental Immunology Study Section (EI)
Program Officer
Mufson, R Allan
Project Start
1997-01-01
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Zhu, Yi; Kim, Young-Mi; Li, Shibo et al. (2010) Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. J Biol Chem 285:26005-12
Ueda-Hayakawa, Ikuko; Mahlios, Josh; Zhuang, Yuan (2009) Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis. J Immunol 182:5306-16
Jia, Jingquan; Dai, Meifang; Zhuang, Yuan (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol 38:2806-20
Hayakawa, Ikuko; Tedder, Thomas F; Zhuang, Yuan (2007) B-lymphocyte depletion ameliorates Sjogren's syndrome in Id3 knockout mice. Immunology 122:73-9
Jones, Mary Elizabeth; Zhuang, Yuan (2007) Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity 27:860-70
Wojciechowski, Jason; Lai, Anne; Kondo, Motonari et al. (2007) E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J Immunol 178:5717-26
Lazorchak, Adam S; Schlissel, Mark S; Zhuang, Yuan (2006) E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol Cell Biol 26:810-21
Lazorchak, Adam S; Wojciechowski, Jason; Dai, Meifang et al. (2006) E2A promotes the survival of precursor and mature B lymphocytes. J Immunol 177:2495-504
Lazorchak, Adam; Jones, Mary Elizabeth; Zhuang, Yuan (2005) New insights into E-protein function in lymphocyte development. Trends Immunol 26:334-8
Li, Hongmei; Dai, Meifang; Zhuang, Yuan (2004) A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity 21:551-60

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