Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA073058-01S1
Application #
2550435
Study Section
Special Emphasis Panel (ZRG2-ET-2 (04))
Project Start
1997-01-15
Project End
1999-11-30
Budget Start
1997-01-15
Budget End
1997-11-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Pharmacology
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Todd, Brian A; Parsegian, V Adrian; Shirahata, Akira et al. (2008) Attractive forces between cation condensed DNA double helices. Biophys J 94:4775-82
Nayvelt, Irina; Thomas, Thresia; Thomas, T J (2007) Mechanistic differences in DNA nanoparticle formation in the presence of oligolysines and poly-L-lysine. Biomacromolecules 8:477-84
Nair, Sandhya K; Verma, Arti; Thomas, T J et al. (2007) Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer Lett 250:311-22
Vijayanathan, Veena; Greenfield, Norma J; Thomas, T J et al. (2007) Effects of estradiol and 4-hydroxytamoxifen on the conformation, thermal stability, and DNA recognition of estrogen receptor beta. Biochem Cell Biol 85:1-10
Vijayanathan, Veena; Thomas, T J; Nair, Sandhya K et al. (2006) Bending of the estrogen response element by polyamines and estrogen receptors alpha and beta: a fluorescence resonance energy transfer study. Int J Biochem Cell Biol 38:1191-1206
Vijayanathan, Veena; Venkiteswaran, Sripriya; Nair, Sandhya K et al. (2006) Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells. Clin Cancer Res 12:2038-48
Lewis, Joan S; Thomas, T J; Pestell, Richard G et al. (2005) Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J Mol Endocrinol 34:91-105
Nair, S K; Thomas, T J; Greenfield, N J et al. (2005) Conformational dynamics of estrogen receptors alpha and beta as revealed by intrinsic tryptophan fluorescence and circular dichroism. J Mol Endocrinol 35:211-23
Lewis, Joan S; Vijayanathan, Veena; Thomas, T J et al. (2005) Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. Oncol Res 15:113-28
Venkiteswaran, Sripriya; Vijayanathan, Veena; Shirahata, Akira et al. (2005) Antisense recognition of the HER-2 mRNA: effects of phosphorothioate substitution and polyamines on DNA.RNA, RNA.RNA, and DNA.DNA duplex stability. Biochemistry 44:303-12

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