Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA078834-04
Application #
6497497
Study Section
Pathobiochemistry Study Section (PBC)
Program Officer
Sathyamoorthy, Neeraja
Project Start
1999-04-05
Project End
2004-01-31
Budget Start
2002-02-01
Budget End
2003-01-31
Support Year
4
Fiscal Year
2002
Total Cost
$249,477
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Evans, Daniel R; Venkitachalam, Srividya; Revoredo, Leslie et al. (2018) Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer. Hum Mutat 39:1092-1101
Sletmoen, Marit; Gerken, Thomas A; Stokke, Bjørn T et al. (2018) Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions. Glycobiology 28:437-442
Revoredo, Leslie; Wang, Shengjun; Bennett, Eric Paul et al. (2016) Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family. Glycobiology 26:360-76
Venkitachalam, Srividya; Revoredo, Leslie; Varadan, Vinay et al. (2016) Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. Sci Rep 6:23642
Haugstad, Kristin E; Hadjialirezaei, Soosan; Stokke, Bjørn T et al. (2016) Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions. Glycobiology 26:1338-1350
Kong, Yun; Joshi, Hiren J; Schjoldager, Katrine Ter-Borch Gram et al. (2015) Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis. Glycobiology 25:55-65
Haugstad, Kristin E; Stokke, Bjørn T; Brewer, C Fred et al. (2015) Single molecule study of heterotypic interactions between mucins possessing the Tn cancer antigen. Glycobiology 25:524-34
Boltin, Doron; Niv, Yaron (2013) Mucins in Gastric Cancer - An Update. J Gastrointest Dig Syst 3:15519
Gerken, Thomas A; Revoredo, Leslie; Thome, Joseph J C et al. (2013) The lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc Ts) acts as a switch directing glycopeptide substrate glycosylation in an N- or C-terminal direction, further controlling mucin type O-glycosylation. J Biol Chem 288:19900-14
Haugstad, Kristin E; Gerken, Thomas A; Stokke, Bjørn T et al. (2012) Enhanced self-association of mucins possessing the T and Tn carbohydrate cancer antigens at the single-molecule level. Biomacromolecules 13:1400-9

Showing the most recent 10 out of 30 publications