Check ThisThe objective of this project is the development of elasticity imaging as a new approach to medical imaging for detection of cancer and monitoring for recurrence. In this research, images are formed by comparing ultrasonic echoes recorded before and after a small physical compression of the tissue. The comparison provides a determination of local tissue displacement that is used to estimate longitudinal strain along the axis of the sound beam. Strain imaging in this way is a kind of palpation technique that reveals stiffness variations in tissues with higher sensitivity and spatial resolution than manual palpation. The proposed approach, which builds on four years of previous research, has six specific aims: 1) Develop robust image formation algorithms for breast imaging. 2) Work with industry to design instrumentation for strain imaging of the breast. 3) Use phantoms to develop breast-tissue-restraining devices. 4) Conduct preliminary clinical trials on human subjects. 5) Examine the diagnostic potential of other elasticity parameters. 6) Assess the performance of developing techniques for the important clinical problem of diagnosing and managing breast disease.
| Toohey, K S; Kalyanam, S; Palaniappan, J et al. (2016) Indentation Analysis of Biphasic Viscoelastic Hydrogels. Mech Mater 92:175-184 |
| Orescanin, Marko; Wang, Yue; Insana, Michael (2011) 3-D FDTD simulation of shear waves for evaluation of complex modulus imaging. IEEE Trans Ultrason Ferroelectr Freq Control 58:389-98 |
| Qayyum, Muqeem A; Insana, Michael F (2011) Effects of radiotherapy fractionation on breast stromal activity. Conf Proc IEEE Eng Med Biol Soc 2011:282-5 |
| Orescanin, Marko; Insana, Michael (2010) Shear modulus estimation with vibrating needle stimulation. IEEE Trans Ultrason Ferroelectr Freq Control 57:1358-67 |
| Wang, Yue; Orescanin, Marko; Insana, Michael F (2010) In vivo measurement of the complex shear modulus of rat mammary tumors using shear wave imaging techniques. Conf Proc IEEE Eng Med Biol Soc 2010:29-32 |
| Orescanin, Marko; Qayyum, Muqeem A; Toohey, Kathleen S et al. (2010) Dispersion and shear modulus measurements of porcine liver. Ultrason Imaging 32:255-66 |
| Yapp, R D; Insana, M F (2009) pH-induced contrast in viscoelasticity imaging of biopolymers. Phys Med Biol 54:1089-109 |
| Kalyanam, Sureshkumar; Yapp, Rebecca D; Insana, Michael F (2009) Poro-viscoelastic behavior of gelatin hydrogels under compression-implications for bioelasticity imaging. J Biomech Eng 131:081005 |
| Orescanin, Marko; Toohey, Kathleen S; Insana, Michael F (2009) Material properties from acoustic radiation force step response. J Acoust Soc Am 125:2928-36 |
| Qiu, Yupeng; Insana, Michael F (2009) Ultrasonic viscoelasticity imaging of nonpalpable breast lesions. Conf Proc IEEE Eng Med Biol Soc 2009:4424-7 |
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