) The long term objective of this project is to advance scientific understanding about the design and function of tobacco products through the acquisition, analysis and reporting of internal tobacco industry documents held in the Minnesota and other court depositories. Particular attention will be paid to the use of additives and the design of low yield cigarettes.
The specific aims of this project include understanding how changes in cigarette design contribute to youth smoking and nicotine dependence. Another aim is to determine how cigarettes are designed to reduce non-smokers' perception of second hand smoke. The project also hopes to improve scientific knowledge about the toxic and addictive properties of cigarettes by reviewing tobacco industry research on smoker behavior, changes in toxic constituents in mainstream and side stream smoke and changes in nicotine delivery over time. This project is relevant to national health policy. The Food and Drug Administration has declared tobacco products to be drug delivery devices and other govemments have proposed regulating tobacco products as drugs to reduce death and diseases associated with their use. This project will provide important scientific infonnation for the better characterization of tobacco product perfonnance and such characterization is essential to tobacco product regulation. The project will electronically access documents from the Minnesota and other depositories for selected topic areas. Relevant documents will be indexed using a standard thesaurus and placed both on the internet as well as searchable CD roms and made available to policy makers and the scientific community. Documents will be analyzed and scientific reports will be written on tobacco product design, regulation and characterization.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA087477-01
Application #
6188934
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (M2))
Program Officer
Bloch, Michele H
Project Start
2000-09-01
Project End
2004-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$235,352
Indirect Cost
Name
Massachusetts State Department of Pub Health
Department
Type
DUNS #
878298900
City
Boston
State
MA
Country
United States
Zip Code
02108
Alpert, Hillel R; Agaku, Israel T; Connolly, Gregory N (2016) A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction. Tob Control 25:444-50
Agaku, Israel T; Vardavas, Constantine I; Ayo-Yusuf, Olalekan A et al. (2014) Gender and racial differences in smoking of long/ultra-long and king size cigarettes among U.S. adult smokers, NHANES 1999-2012. Drug Alcohol Depend 136:28-35
Sokol, Natasha A; Kennedy, Ryan David; Connolly, Gregory N (2014) The role of cocoa as a cigarette additive: opportunities for product regulation. Nicotine Tob Res 16:984-91
Alpert, Hillel R; Christiani, David C; Orav, E John et al. (2014) Effectiveness of the cigarette ignition propensity standard in preventing unintentional residential fires in Massachusetts. Am J Public Health 104:e56-61
Connolly, Gregory N; Alpert, Hillel R (2014) Has the tobacco industry evaded the FDA's ban on 'Light' cigarette descriptors? Tob Control 23:140-5
Agaku, Israel T; Vardavas, Constantine I; Connolly, Gregory N (2014) Cigarette rod length and its impact on serum cotinine and urinary total NNAL levels, NHANES 2007-2010. Nicotine Tob Res 16:100-7
Agaku, Israel T; Ayo-Yusuf, Olalekan A; Vardavas, Constantine I et al. (2014) Predictors and patterns of cigarette and smokeless tobacco use among adolescents in 32 countries, 2007-2011. J Adolesc Health 54:47-53
Agaku, Israel T; Vardavas, Constantine I; Connolly, Gregory (2013) Proposed cutoff for identifying adult smokeless tobacco users with urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonol: an aggregated analysis of NHANES 2007-2010 data. Nicotine Tob Res 15:1956-61
Kennedy, Ryan David; Millstein, Rachel A; Rees, Vaughan W et al. (2013) Tobacco industry strategies to minimize or mask cigarette smoke: opportunities for tobacco product regulation. Nicotine Tob Res 15:596-602
Agaku, Israel T; Ayo-Yusuf, Olalekan A; Vardavas, Constantine I et al. (2013) Use of conventional and novel smokeless tobacco products among US adolescents. Pediatrics 132:e578-86

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