Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA100322-01S1
Application #
6878286
Study Section
Virology Study Section (VR)
Program Officer
Cole, John S
Project Start
2003-06-01
Project End
2008-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
1
Fiscal Year
2004
Total Cost
$13,250
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Heyrana, Katrina J; Goh, Boon Chong; Perilla, Juan R et al. (2016) Contributions of Charged Residues in Structurally Dynamic Capsid Surface Loops to Rous Sarcoma Virus Assembly. J Virol 90:5700-5714
Goh, Boon Chong; Perilla, Juan R; England, Matthew R et al. (2015) Atomic Modeling of an Immature Retroviral Lattice Using Molecular Dynamics and Mutagenesis. Structure 23:1414-1425
England, Matthew R; Purdy, John G; Ropson, Ira J et al. (2014) Potential role for CA-SP in nucleating retroviral capsid maturation. J Virol 88:7170-7
Keller, Paul W; Huang, Rick K; England, Matthew R et al. (2013) A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition. J Virol 87:13655-64
Dalessio, Paula M; Craven, Rebecca C; Lokhandwala, Parvez M et al. (2013) Lethal mutations in the major homology region and their suppressors act by modulating the dimerization of the rous sarcoma virus capsid protein C-terminal domain. Proteins 81:316-25
Butan, Carmen; Lokhandwala, Parvez M; Purdy, John G et al. (2010) Suppression of a morphogenic mutant in Rous sarcoma virus capsid protein by a second-site mutation: a cryoelectron tomography study. J Virol 84:6377-86
Cardone, Giovanni; Purdy, John G; Cheng, Naiqian et al. (2009) Visualization of a missing link in retrovirus capsid assembly. Nature 457:694-8
Purdy, John G; Flanagan, John M; Ropson, Ira J et al. (2009) Retroviral capsid assembly: a role for the CA dimer in initiation. J Mol Biol 389:438-51
Lokhandwala, Parvez M; Nguyen, Tam-Linh N; Bowzard, J Bradford et al. (2008) Cooperative role of the MHR and the CA dimerization helix in the maturation of the functional retrovirus capsid. Virology 376:191-8
Butan, Carmen; Winkler, Dennis C; Heymann, J Bernard et al. (2008) RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis. J Mol Biol 376:1168-81

Showing the most recent 10 out of 14 publications