Abstract

The aim of this work is to define genetic determinants of the responses to morphine in mice. In addition, we are examining the role of catecholamine metabolism in the sensitization of mice to morphine, cocaine and methylphenidate. Mutant strains have been identified that differ in their analgesic and motor responses to morphine. We will measure narcotic receptors, enkephalins and beta endorphin levels in several brain regions of mice from the mutant and parental strains. We also plan to measure dopamine turnover and the number of dopamine receptors in mice that have been sensitized to morphine, to methylphenidate and to cocaine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA001626-09
Application #
3206963
Study Section
Pharmacology I Research Subcommittee (DABR)
Project Start
1977-12-01
Project End
1986-08-31
Budget Start
1985-03-01
Budget End
1986-08-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Faraone, Stephen V; Biederman, Joseph; Wilens, Timothy E et al. (2007) A naturalistic study of the effects of pharmacotherapy on substance use disorders among ADHD adults. Psychol Med 37:1743-52
Miczek, K A; Thompson, M L; Shuster, L (1986) Analgesia following defeat in an aggressive encounter: development of tolerance and changes in opioid receptors. Ann N Y Acad Sci 467:14-29
Shuster, L (1986) Genetic markers of drug abuse in mouse models. NIDA Res Monogr 66:71-85
Miczek, K A; Thompson, M L; Shuster, L (1985) Naloxone injections into the periaqueductal grey area and arcuate nucleus block analgesia in defeated mice. Psychopharmacology (Berl) 87:39-42