Abstract

The role of nicotine as a reinforcing agent in tobacco will be investigated as a function of several key variables: 1) smoking deprivation and satiation; 2) conditioned stimuli accompanying inhalation of nicotine; 3) other constituents in tobacco (tar); and 4) situationally induced anxiety (performing while being videotaped). While manipulating these influences systematically in the following experiments, nicotine's reinforcing value will be measured behaviorally using a smoke mixing device that allows subjects to adjust the nicotine delivery of each puff they take. Preferred nicotine levels, puffing and volume of smoke taken in will comprise the dependent measures of smoking. Our goal is to pinpoint the critical pharmacological and psychological variables mediating smoking satisfaction. In so doing, less harmful substitutes may be developed which preserve the reinforcers sought by smokers, and reduce the health risks to which they are currently exposed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA002665-05
Application #
3207496
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1981-09-30
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Rose, Jed E; Salley, Al; Behm, Frederique M et al. (2010) Reinforcing effects of nicotine and non-nicotine components of cigarette smoke. Psychopharmacology (Berl) 210:1-12
Rose, Jed E; Behm, Frederique M; Westman, Eric C et al. (2006) Precessation treatment with nicotine skin patch facilitates smoking cessation. Nicotine Tob Res 8:89-101
Rose, Jed E; Behm, Frederique M (2004) Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments. Nicotine Tob Res 6:523-32
Rose, Jed E; Behm, Frederique M; Westman, Eric C et al. (2003) Pharmacologic and sensorimotor components of satiation in cigarette smoking. Pharmacol Biochem Behav 76:243-50
Rose, Jed E; Behm, Frederique M; Westman, Eric C et al. (2003) Mecamylamine acutely increases human intravenous nicotine self-administration. Pharmacol Biochem Behav 76:307-13
Rose, J E; Behm, F M; Westman, E C (2001) Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking. Pharmacol Biochem Behav 68:187-97
Rose, J E; Behm, F M; Westman, E C et al. (2000) Dissociating nicotine and nonnicotine components of cigarette smoking. Pharmacol Biochem Behav 67:71-81
Rose, J E; Westman, E C; Behm, F M et al. (1999) Blockade of smoking satisfaction using the peripheral nicotinic antagonist trimethaphan. Pharmacol Biochem Behav 62:165-72
Rose, J E; Behm, F M; Westman, E C et al. (1999) Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction. Drug Alcohol Depend 56:99-107
Rose, J E; Corrigall, W A (1997) Nicotine self-administration in animals and humans: similarities and differences. Psychopharmacology (Berl) 130:28-40

Showing the most recent 10 out of 37 publications