Abstract

Repeated cocaine administration sometimes results in tolerance and sometimes in sensitization to the drug's subsequent effects. Variables responsible for this dichotomous set of outcomes have yet to be elucidated fully, but it is clear that behavioral factors may play a role. In preliminary work we found that the amount of responding required for reinforcement could modulate the degree of tolerance that developed when cocaine was administered repeatedly. In the research proposed here we shall analyze this effect and examine its generality. Specifically, the roles of reinforcement frequency and """"""""effort"""""""" will be analyzed. In addition, interspecies generality (pigeons vs. squirrel monkeys) will be assessed as will the generality of the effect to other contingency arrangements. Identification and characterization of behavioral factors that modulate the development of tolerance to cocaine's effects could have important implications for treatment and prevention of abuse.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004074-02
Application #
3209103
Study Section
Drug Abuse Clinical and Behavioral Research Review Committee (DACB)
Project Start
1986-04-01
Project End
1988-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Type
Schools of Arts and Sciences
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Panin, Vladislav M; Wells, Lance (2014) Protein O-mannosylation in metazoan organisms. Curr Protoc Protein Sci 75:Unit 12.12.
Minervini, Vanessa; Branch, Marc N (2013) Tolerance to cocaine's effects following chronic administration of a dose without detected effects on response rate or pause. J Exp Anal Behav 100:316-32
Macaskill, Anne C; Branch, Marc N (2012) Tolerance to cocaine's effects on schedule-controlled behavior: role of delay between pause-ending responses and reinforcement. Pharmacol Biochem Behav 100:616-23
Kangas, Brian D; Branch, Marc N (2012) Relations among acute and chronic nicotine administration, short-term memory, and tactics of data analysis. J Exp Anal Behav 98:155-67
Berry, Meredith S; Kangas, Brian D; Branch, Marc N (2012) Development of key-pecking, pause, and ambulation during extended exposure to a fixed-interval schedule of reinforcement. J Exp Anal Behav 97:333-46
Kangas, Brian D; Branch, Marc N (2012) Effects of acute and chronic cocaine administration on titrating-delay matching-to-sample performance. J Exp Anal Behav 97:151-61
Branch, Marc N (2011) Is translation the problem? Some reactions to critchfield (2011). Behav Anal 34:19-22
Kangas, Brian D; Berry, Meredith S; Branch, Marc N (2011) On the development and mechanics of delayed matching-to-sample performance. J Exp Anal Behav 95:221-36
Pinkston, Jonathan W; Branch, Marc N (2010) Acute and chronic effects of cocaine on the spontaneous behavior of pigeons. J Exp Anal Behav 94:25-36
Weaver, Matthew T; Dallery, Jesse; Branch, Marc N (2010) Response topography in behavioral tolerance to cocaine with rats. Behav Pharmacol 21:660-7

Showing the most recent 10 out of 49 publications