Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004089-11
Application #
2116965
Study Section
Special Emphasis Panel (SRCD)
Project Start
1985-08-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Preston, K L; Bigelow, G E (2000) Effects of agonist-antagonist opioids in humans trained in a hydromorphone/not hydromorphone discrimination. J Pharmacol Exp Ther 295:114-24
Jones, H E; Bigelow, G E; Preston, K L (1999) Assessment of opioid partial agonist activity with a three-choice hydromorphone dose-discrimination procedure. J Pharmacol Exp Ther 289:1350-61
Preston, K L; Bigelow, G E (1998) Opioid discrimination in humans: discriminative and subjective effects of progressively lower training dose. Behav Pharmacol 9:533-43
Dykstra, L A; Preston, K L; Bigelow, G E (1997) Discriminative stimulus and subjective effects of opioids with mu and kappa activity: data from laboratory animals and human subjects. Psychopharmacology (Berl) 130:14-27
Preston, K L; Bigelow, G E (1994) Drug discrimination assessment of agonist-antagonist opioids in humans: a three-choice saline-hydromorphone-butorphanol procedure. J Pharmacol Exp Ther 271:48-60
Preston, K L; Bigelow, G E (1993) Differential naltrexone antagonism of hydromorphone and pentazocine effects in human volunteers. J Pharmacol Exp Ther 264:813-23
Strain, E C; Preston, K L; Liebson, I A et al. (1993) Precipitated withdrawal by pentazocine in methadone-maintained volunteers. J Pharmacol Exp Ther 267:624-34
Strain, E C; Preston, K L; Liebson, I A et al. (1992) Acute effects of buprenorphine, hydromorphone and naloxone in methadone-maintained volunteers. J Pharmacol Exp Ther 261:985-93
Weinhold, L L; Preston, K L; Farre, M et al. (1992) Buprenorphine alone and in combination with naloxone in non-dependent humans. Drug Alcohol Depend 30:263-74
Bigelow, G E; Preston, K L (1992) Assessment of buprenorphine in a drug discrimination procedure in humans. NIDA Res Monogr 121:28-37

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