The goal of this continuation is to study the motivational processes involved in eating behavior, and to determine how drugs that affect food consumption alter these processes. Animals will control their own pattern of daily food consumption using a procedure that provides measures of food seeking, food taking, and the motivational or incentive salience of stimuli paired with food. We hypothesize that anorectic drugs may decrease total daily food consumption by decreasing food seeking and/or food taking, which may occur independently of changes in incentive salience. We will first determine the effects of naturalistic manipulations on food-related behavior and test the generalizability of our model by studying behavior related to another reinforcer, candy. Data implicate dopamine (DA) in mediating motivational processes, with increased DA levels associated with increased incentive salience of a stimulus. Less well developed are findings that suggest that serotonin (5- HT) may also play a role in motivational processes that is oppositional to that played by DA. We will determine the effects of drugs that decrease food consumption (amphetamine, dexfenfluramine, sibutramine, acamprosate) and increase food consumption (alprazolam, delta9-THC, baclofen, MK-801), via different neurotransmitter systems, on food-related behavior. Finally, because MK-801 has been shown to slow the development of sensitization to stimulants and alter the effects of repeated administration of drugs of abuse, we will also determine whether MK-801 will alter the behavioral effects of repeated doses of amphetamine and sibutramine. This research will provide further information about the behavioral mechanisms of action of anorectic drugs with an emphasis on motivational processes. We hypothesize that drugs of abuse will alter both food seeking and the incentive salience of stimuli paired with food. A better understanding of the neuropharmacological systems that are involved in motivation will be an asset in the development of drugs that affect eating behavior and other appetitive behaviors, including drug abuse.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
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Special Emphasis Panel (ZRG1-BBBP-1 (01))
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Wetherington, Cora Lee
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New York State Psychiatric Institute
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Foltin, Richard W; Evans, Suzette M (2018) Sex differences in the anorexigenic effects of dexfenfluramine and amphetamine in baboons. Exp Clin Psychopharmacol 26:335-340
Foltin, Richard W (2018) Self-administration of methamphetamine aerosol by male and female baboons. Pharmacol Biochem Behav 168:17-24
Wu, Melody V; Shamy, Jul Lea; Bedi, Gillinder et al. (2014) Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus. Neuropsychopharmacology 39:1861-71
Foltin, Richard W (2012) The behavioral pharmacology of anorexigenic drugs in nonhuman primates: 30 years of progress. Behav Pharmacol 23:461-77
Foltin, Richard W (2011) Consumption of palatable food decreases the anorectic effects of serotonergic, but not dopaminergic drugs in baboons. Physiol Behav 103:493-500
Foltin, Richard W; Danysz, Wojciech; Bisaga, Adam (2008) A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine. Psychopharmacology (Berl) 199:583-92
Bisaga, Adam; Danysz, Wojciech; Foltin, Richard W (2008) Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder. Eur Neuropsychopharmacol 18:794-802
Foltin, Richard W; Haney, Margaret (2007) Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates. Pharmacol Biochem Behav 86:766-73
Zernig, Gerald; Ahmed, Serge H; Cardinal, Rudolf N et al. (2007) Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests. Pharmacology 80:65-119
Foltin, Richard W (2006) ""Tasting and wasting"" behavior in non-human primates: aberrant behavior or normal behavior in ""times of plenty"". Physiol Behav 89:587-97

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