Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004248-09
Application #
2117097
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1990-04-01
Project End
1997-01-31
Budget Start
1995-07-01
Budget End
1997-01-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Arizona
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Bird, M F; Vardanyan, R S; Hruby, V J et al. (2015) Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands. Br J Anaesth 114:646-56
Soloshonok, Vadim A; Cai, Chaozhong; Yamada, Takeshi et al. (2005) Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically cont J Am Chem Soc 127:15296-303
Soloshonok, Vadim A; Ueki, Hisanori; Tiwari, Rohit et al. (2004) Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta J Org Chem 69:4984-90
Okayama, T; Burritt, A; Hruby, V J (2000) 4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics. Org Lett 2:1787-90
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Soloshonok, V A; Cai, C; Hruby, V J (2000) (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives. Org Lett 2:747-50
Tang, Q; Lynch, R M; Porreca, F et al. (2000) Dynorphin A elicits an increase in intracellular calcium in cultured neurons via a non-opioid, non-NMDA mechanism. J Neurophysiol 83:2610-5
Soloshonok, V A; Cai, C; Hruby, V J et al. (2000) Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions. J Org Chem 65:6688-96
Hruby, V J; Agnes, R S (1999) Conformation-activity relationships of opioid peptides with selective activities at opioid receptors. Biopolymers 51:391-410
Tang, Q; Gandhoke, R; Burritt, A et al. (1999) High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors. J Pharmacol Exp Ther 291:760-5

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