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Hook, Vivian; Bandeira, Nuno (2015) Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems. J Am Soc Mass Spectrom 26:1970-80
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Podvin, Sonia; Bundey, Richard; Toneff, Thomas et al. (2015) Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Mol Cell Neurosci 68:177-85
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Toneff, Thomas; Funkelstein, Lydiane; Mosier, Charles et al. (2013) Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides 46:126-35
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Wahlert, Andrew; Funkelstein, Lydiane; Fitzsimmons, Bethany et al. (2013) Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides 47:109-15
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Hook, Vivian; Funkelstein, Lydiane; Wegrzyn, Jill et al. (2012) Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta 1824:89-104
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Bark, Steven J; Wegrzyn, Jill; Taupenot, Laurent et al. (2012) The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases. PLoS One 7:e41134
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Lu, Weiya D; Liu, Tong; Li, Sheng et al. (2012) The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Sci 21:178-87
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Lu, Weiya Douglas; Funkelstein, Lydiane; Toneff, Thomas et al. (2012) Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters. J Neurochem 122:512-22
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Kindy, Mark S; Yu, Jin; Zhu, Hong et al. (2012) Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing A?PP containing the wild-type ?-secretase site sequence. J Alzheimers Dis 29:827-40
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Funkelstein, Lydiane; Lu, W Douglas; Koch, Britta et al. (2012) Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. J Biol Chem 287:15232-41
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