The overall objective of the proposed research is to provide an experimental analysis of the effects of cocaine on sensory and motor function in non-human primates. Animal psychophysical procedures will be employed to obtain quantitative assessments of the effects of cocaine on the following aspects of sensory function: 1) absolute auditory thresholds; 2) absolute visual thresholds; 3) the discrimination of auditory frequency differences; and 4) discrimination of synthetic speech sounds. For each of these aspects of sensory function, motor function will also be assessed by examining reaction times to each type of sensory stimulus employed. All experiments will be conducted using a standard reaction time procedure with non-restrained laboratory baboons. The proposed research will assess the effects of both acute and chronic cocaine dosing regimens on sensory/motor function, and will also examine the effects of doses of cocaine combined with other drugs of abuse (ethanol, delta-9-THC, pentobarbital). The results will provide basic data on the effects of cocaine on sensory and motor function across a range of drug doses, and on the interaction effects of cocaine with other common drugs of abuse. The study will also provide information relevant to drug scheduling and clinical evaluation of functional decrements produced by cocaine.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA004731-04
Application #
3210394
Study Section
Special Emphasis Panel (SRCD (23))
Project Start
1988-05-01
Project End
1993-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Hienz, Robert D; Jones, April M; Weerts, Elise M (2004) The discrimination of baboon grunt calls and human vowel sounds by baboons. J Acoust Soc Am 116:1692-7
Hienz, Robert D; Weed, Michael R; Zarcone, Troy J et al. (2003) Cocaine's effects on detection, discrimination, and identification of auditory stimuli by baboons. Pharmacol Biochem Behav 74:287-96
Hienz, Robert D; Weed, Michael R; Zarcone, Troy J et al. (2002) Cocaine's effects on the discrimination of simple and complex auditory stimuli by baboons. Pharmacol Biochem Behav 72:825-33
Hienz, R D; Zarcone, T J; Brady, J V (2001) Perceptual and motor effects of morphine and buprenorphine in baboons. Pharmacol Biochem Behav 69:305-13
Hienz, R D; Zarcone, T J; Pyle, D A et al. (1997) Effects of cocaine and quinpirole on perceptual and motor functions in baboons. Psychopharmacology (Berl) 134:38-45
Hienz, R D; Zarcone, T J; Pyle, D A et al. (1996) Cocaine's effects on speech sound identification and reaction times in baboons. Psychopharmacology (Berl) 125:120-8
Hienz, R D; Spear, D J; Pyle, D A et al. (1995) Cocaine's effects on speech sound discriminations and reaction times in baboons. Psychopharmacology (Berl) 122:147-57
Hienz, R D; Spear, D J; Bowers, D A (1994) Effects of cocaine on simple reaction times and sensory thresholds in baboons. J Exp Anal Behav 61:231-46
Hienz, R D; Spear, D J; Brady, J V et al. (1993) Effects of cocaine on sensory motor function in baboons. Pharmacol Biochem Behav 45:399-408
Hienz, R D; Turkkan, J S; Spear, D J et al. (1992) General activity in baboons measured with a computerized, lightweight piezoelectric motion sensor: effects of drugs. Pharmacol Biochem Behav 42:497-507