Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006312-08
Application #
2118643
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1989-09-30
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Saint Louis University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103

  Publications

Grace, Christy R R; Cowsik, Sudha M; Shim, Joong-Youn et al. (2007) Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. J Struct Biol 159:359-68
Mukhopadhyay, Somnath; Das, Sucharita; Williams, Evelyn A et al. (2006) Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages. J Neuroimmunol 181:82-92
Shim, Joong-Youn; Howlett, Allyn C (2006) WIN55212-2 docking to the CB1 cannabinoid receptor and multiple pathways for conformational induction. J Chem Inf Model 46:1286-300
Mukhopadhyay, Somnath; Howlett, Allyn C (2005) Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions. Mol Pharmacol 67:2016-24
Shim, Joong-Youn; Howlett, Allyn C (2004) Steric trigger as a mechanism for CB1 cannabinoid receptor activation. J Chem Inf Comput Sci 44:1466-76
Shim, Joong-Youn; Welsh, William J; Howlett, Allyn C (2003) Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers 71:169-89
Shim, Joong-Youn; Welsh, William J; Cartier, Etienne et al. (2002) Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. J Med Chem 45:1447-59
Mukhopadhyay, Somnath; Shim, Joong-Youn; Assi, Abdel-Azim et al. (2002) CB(1) cannabinoid receptor-G protein association: a possible mechanism for differential signaling. Chem Phys Lipids 121:91-109
Meschler, J P; Kraichely, D M; Wilken, G H et al. (2000) Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871) for th Biochem Pharmacol 60:1315-23
Howlett, A C; Wilken, G H; Pigg, J J et al. (2000) Azido- and isothiocyanato-substituted aryl pyrazoles bind covalently to the CB1 cannabinoid receptor and impair signal transduction. J Neurochem 74:2174-81

Showing the most recent 10 out of 26 publications