Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA007223-11
Application #
6515451
Study Section
Special Emphasis Panel (ZRG1-SSS-Q (01))
Program Officer
Lin, Geraline
Project Start
1991-06-01
Project End
2004-05-31
Budget Start
2002-09-30
Budget End
2003-05-31
Support Year
11
Fiscal Year
2002
Total Cost
$175,000
Indirect Cost
Name
University of Toronto
Department
Type
DUNS #
259999779
City
Toronto
State
ON
Country
Canada
Zip Code
M5 1-S8
Hasbi, Ahmed; Perreault, Melissa L; Shen, Maurice Y F et al. (2017) Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ?FosB. Front Pharmacol 8:924
Perreault, Melissa L; Hasbi, Ahmed; Shen, Maurice Y F et al. (2016) Disruption of a dopamine receptor complex amplifies the actions of cocaine. Eur Neuropsychopharmacol 26:1366-1377
Perreault, M L; Shen, M Y F; Fan, T et al. (2015) Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer. Neuroscience 285:194-203
Shen, Maurice Y F; Perreault, Melissa L; Fan, Theresa et al. (2015) The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. Pharmacol Biochem Behav 128:33-40
Hasbi, Ahmed; Perreault, Melissa L; Shen, Maurice Y F et al. (2014) A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism. FASEB J 28:4806-20
Perreault, Melissa L; Hasbi, Ahmed; O'Dowd, Brian F et al. (2014) Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance. Neuropsychopharmacology 39:156-68
Perreault, Melissa L; Jones-Tabah, Jace; O'Dowd, Brian F et al. (2013) A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol 16:477-83
Perreault, Melissa L; Fan, Theresa; O'Dowd, Brian F et al. (2013) Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Dev Neurosci 35:384-95
Ting-A-Kee, Ryan; Mercuriano, Laura E; Vargas-Perez, Hector et al. (2013) Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner. Behav Brain Res 247:174-177
O'Dowd, Brian F; Nguyen, Tuan; Ji, Xiaodong et al. (2013) D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation. Biochem Biophys Res Commun 431:586-9

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