Abstract

This continuation application takes its impetus from the significant findings of the current study, which reported the existence of a characteristic profile of quantitative EEG (QEEG) changes associated with cocaine dependence, and demonstrated persistence of this profile during six months of abstinence. Further, subtypes were found with distinctive QEEG profiles at baseline (5-14 days abstinent). Significant interactions existed between QEEG subtype, gender, comorbidity, and treatment outcome; A regression equation using a subset of QEEG baseline measures yielded highly significant (p

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA007707-04A1
Application #
2412087
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
1993-04-01
Project End
2000-02-29
Budget Start
1997-04-01
Budget End
1998-02-28
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Alper, Kenneth; Shah, Jaini; Howard, Bryant et al. (2013) Childhood abuse and EEG source localization in crack cocaine dependence. Psychiatry Res 213:63-70
Reid, Malcolm S; Flammino, Frank; Howard, Bryant et al. (2008) Cocaine cue versus cocaine dosing in humans: evidence for distinct neurophysiological response profiles. Pharmacol Biochem Behav 91:155-64
Reid, Malcolm S; Flammino, Frank; Howard, Bryant et al. (2006) Topographic imaging of quantitative EEG in response to smoked cocaine self-administration in humans. Neuropsychopharmacology 31:872-84
Prichep, Leslie S; Alper, Kenneth R; Sverdlov, Lev et al. (2002) Outcome related electrophysiological subtypes of cocaine dependence. Clin Electroencephalogr 33:8-20
Prichep, L S; Alper, K R; Kowalik, S C et al. (1999) Prediction of treatment outcome in cocaine dependent males using quantitative EEG. Drug Alcohol Depend 54:35-43
Alper, K R; Prichep, L S; Kowalik, S et al. (1998) Persistent QEEG abnormality in crack cocaine users at 6 months of drug abstinence. Neuropsychopharmacology 19:1-9
Prichep, L S; Alper, K R; Kowalik, S et al. (1996) Quantitative electroencephalographic characteristics of crack cocaine dependence. Biol Psychiatry 40:986-93
Prichep, L S; Alper, K; Kowalik, S C et al. (1996) Neurometric QEEG studies of crack cocaine dependence and treatment outcome. J Addict Dis 15:39-53
Prichep, L S; Kowalik, S C; Alper, K et al. (1995) Quantitative EEG characteristics of children exposed in utero to cocaine. Clin Electroencephalogr 26:166-72