During abstinence, the short- and long-term sequelae of repeated dose (""""""""binge"""""""") cocaine use may have a substantial impact on the likelihood of relapse to cocaine use. The focus of this renewal is on the behavior and neurochemical changes of cocaine users during and after a smoked cocaine binge. Sex differences in subjective-effects, task performance, responsivity to drug-related cues, sleep, and neuroendocrine response to agonist challenges will be assessed for 2 weeks after binge cocaine use.
Aim 1. Examine prolactin (PRL) release following the administration of the serotonin (5HT) agonist dexfenfluramine in female cocaine users 2, 8, and 14 days after a cocaine binge during the follicular phase of the menstrual cycle. Hypothesis: The closer in time to the cocaine binge that dexfenfluramine is given, the smaller the increase in PRL levels.
Aim 2. Examine PRL release following the administration of the dopamine (DA) agonist bromocriptine in abstinent male and female cocaine users 2, 8, and 14 days after a cocaine binge. Hypothesis: The closer in time to the cocaine binge that bromocriptine is given, the smaller the decrease in PRL levels. We will compare the neuro-endocrine response to bromocriptine and dexfenfluramine in abstinent cocaine users to the responses observed in groups of non-drug users matched for age, sex, and menstrual cycle phase.
Aim 3. Examine responsivity to previously neutral stimuli, that have been paired with cocaine and placebo during training sessions, as a function of time since last cocaine use. Hypotheses: Stimuli paired with cocaine will elicit cocaine craving, alter mood, and disrupt cognitive task performance. Responsivity to stimuli will vary as a function of time since last cocaine use.
Aim 4. Examine the responses to smoked cocaine over the course of a 3-day binge of smoked cocaine use in female cocaine users, comparing the acute and residual effects of a cocaine binge during the follicular and mid-luteal phases of the menstrual cycle. Hypothesis: Within-session tolerance to the effects of cocaine will develop independently of menstrual cycle phase, but will not carry over from session to session within a day or between days. The proposed studies will provide data relevant to the behavioral and neurochemical mechanisms impacting the likelihood of relapse to cocaine use.
|Vadhan, Nehal P; Myers, Catherine E; Benedict, Elysia et al. (2014) A decrement in probabilistic category learning in cocaine users after controlling for marijuana and alcohol use. Exp Clin Psychopharmacol 22:65-74|
|Kalapatapu, Raj K; Bedi, Gillinder; Haney, Margaret et al. (2012) Substance use after participation in laboratory studies involving smoked cocaine self-administration. Drug Alcohol Depend 120:162-7|
|Kalapatapu, Raj K; Bedi, Gillinder; Haney, Margaret et al. (2012) The subjective effects of cocaine: relationship to years of cocaine use and current age. Am J Drug Alcohol Abuse 38:530-4|
|Reed, Stephanie Collins; Evans, Suzette M; Bedi, Gillinder et al. (2011) The effects of oral micronized progesterone on smoked cocaine self-administration in women. Horm Behav 59:227-35|
|Vosburg, Suzanne K; Haney, Margaret; Rubin, Eric et al. (2010) Using a novel alternative to drug choice in a human laboratory model of a cocaine binge: a game of chance. Drug Alcohol Depend 110:144-50|
|Evans, Suzette M; Foltin, Richard W (2010) Does the response to cocaine differ as a function of sex or hormonal status in human and non-human primates? Horm Behav 58:13-21|
|Reed, Stephanie Collins; Haney, Margaret; Evans, Suzette M et al. (2009) Cardiovascular and subjective effects of repeated smoked cocaine administration in experienced cocaine users. Drug Alcohol Depend 102:102-7|
|Vadhan, Nehal P; Myers, Catherine E; Rubin, Eric et al. (2008) Stimulus-response learning in long-term cocaine users: acquired equivalence and probabilistic category learning. Drug Alcohol Depend 93:155-62|
|Collins, Stephanie L; Evans, Suzette M; Foltin, Richard W et al. (2007) Intranasal cocaine in humans: effects of sex and menstrual cycle. Pharmacol Biochem Behav 86:117-24|
|Vadhan, Nehal P; Carpenter, Kenneth M; Copersino, Marc L et al. (2007) Attentional bias towards cocaine-related stimuli: relationship to treatment-seeking for cocaine dependence. Am J Drug Alcohol Abuse 33:727-36|
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