Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA009315-02
Application #
2122464
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1995-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Ouyang, Hui; Chen, Weiqing; Andersen, Thomas E et al. (2009) Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa. J Pharm Sci 98:337-48
Ouyang, Hui; Andersen, Thomas E; Chen, Weiqing et al. (2009) A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE). J Pharm Sci 98:2227-36
Ouyang, Hui; Chen, Weiqing; Andersen, Thomas E et al. (2009) Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa. J Pharm Sci 98:349-61
Liederer, Bianca M; Fuchs, Tarra; Vander Velde, David et al. (2006) Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides. J Med Chem 49:1261-70
Tang, Fuxing; Ouyang, Hui; Yang, Jerry Z et al. (2004) Bidirectional transport of rhodamine 123 and Hoechst 33342, fluorescence probes of the binding sites on P-glycoprotein, across MDCK-MDR1 cell monolayers. J Pharm Sci 93:1185-94
Horie, Kazutoshi; Tang, Fuxing; Borchardt, Ronald T (2003) Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res 20:161-8
Chen, Weiqing; Yang, Jerry Z; Andersen, Rikke et al. (2002) Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model. J Pharmacol Exp Ther 303:849-57
Yang, Jerry Z; Bastian, K Chad; Moore, Randy D et al. (2002) Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. J Chromatogr B Analyt Technol Biomed Life Sci 780:269-81
Ouyang, Hui; Tang, Fuxing; Siahaan, Teruna J et al. (2002) A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics. Pharm Res 19:794-801
Tang, Fuxing; Horie, Kazutoshi; Borchardt, Ronald T (2002) Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res 19:765-72

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