IDUs occupy a central position in the HIV epidemic; they are the second leading risk group and the principal source for heterosexual transmission of the disease in the United States. Among females, drug injection plays an even more significant role as it is their greatest risk factor, followed by heterosexual contact with an infected male. One-third of out-of- treatment IDU's interviewed in Denver from 1992-1993 reported injecting with a needle that they knew had previously been used by another IDU without disinfecting it first. Moreover, relapse to high-risk behaviors is common among those who initiate risk reduction. These findings call for the development and study of interventions that go beyond encouraging safer drug use. We are responding to this need by proposing a controlled test of a manual driven intervention that integrates street outreach by community coworkers and formal substance abuse treatment services. It is a prospective study, with a two-by-two factorial design and random assignment of 880 IDUs to one of four conditions; 1) a street-based, individual risk assessment (IRA) intervention conducted by community outreach workers teaching safer drug and sex practices; 2) the same IRA intervention but with the addition of free substance abuse treatment for 90 days (IRA-T); 3) an enhanced individual risk assessment (EIRA) intervention, in which community outreach workers initially provide the IRA intervention but then perform in a role-induction capacity, using motivational interviewing techniques and following the stages of change model, in order to encourage and facilitate treatment entry and, subsequently, reinforce clients' decision to remain in treatment; or 4) the EIRA intervention with 90 days of free substance treatment (EIRA-T). It is hypothesized that treatment entry, treatment compliance, and treatment retention will be significantly greater among subjects assigned to the EIRA, as well as to free treatment interventions, compared to the IRA and non-free treatment interventions. Lower frequencies of drug use, reflected tin self-reports and verified through urinalysis, and greater HIV risk-reduction, will significantly favor subjects assigned to the EIRA interventions compared tot he IRA interventions, as well as subjects assigned to free treatment compared to non-free treatment. The stages of change model will be used to measure readiness for change and as an outcome measure to evaluate the effectiveness of the four interventions in modifying specific drug-related behaviors. Using this model, subjects assigned to the EIRA interventions will show more progressive movement then will subjects assigned to the IRA interventions. Perceived self-efficacy will also reflect greater improvement by EIRA subjects than by IRA subjects, and perceived self-efficacy will be significantly associated with behavior change. It is also hypothesized that the EIRA-T intervention will be more cost-beneficial than will either of the IRA interventions. The study will be evaluated using formative and summative methodologies with emphasis on assessing intervention dose response and its relation to outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA009832-05
Application #
2897971
Study Section
Special Emphasis Panel (SRCD (51))
Program Officer
Hilton, Thomas
Project Start
1995-07-15
Project End
2000-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Corsi, Karen F; Lehman, Wayne K; Booth, Robert E (2009) The effect of methadone maintenance on positive outcomes for opiate injection drug users. J Subst Abuse Treat 37:120-6
Corsi, Karen F; Kwiatkowski, Carol F; Booth, Robert E (2007) Treatment entry and predictors among opiate-using injection drug users. Am J Drug Alcohol Abuse 33:121-7
Booth, Robert E; Lehman, Wayne E; Brewster, John T et al. (2007) Gender differences in sex risk behaviors among Ukraine injection drug users. J Acquir Immune Defic Syndr 46:112-7
Booth, Robert E; Kwiatkowski, Carol F; Mikulich-Gilbertson, Susan K et al. (2006) Predictors of risky needle use following interventions with injection drug users in Ukraine. Drug Alcohol Depend 82 Suppl 1:S49-55
Booth, Robert E; Mikulich-Gilbertson, Susan K; Brewster, John T et al. (2004) Predictors of self-reported HIV infection among drug injectors in Ukraine. J Acquir Immune Defic Syndr 35:82-8
Booth, Robert E; Corsi, Karen F; Mikulich-Gilbertson, Susan K (2004) Factors associated with methadone maintenance treatment retention among street-recruited injection drug users. Drug Alcohol Depend 74:177-85
Booth, Robert E; Corsi, Karen F; Mikulich, Susan K (2003) Improving entry to methadone maintenance among out-of-treatment injection drug users. J Subst Abuse Treat 24:305-11
Kwiatkowski, Carol F; Fortuin Corsi, Karen; Booth, Robert E (2002) The association between knowledge of hepatitis C virus status and risk behaviors in injection drug users. Addiction 97:1289-94
John, D; Kwiatkowski, C F; Booth, R E (2001) Differences among out-of-treatment drug injectors who use stimulants only, opiates only or both: implications for treatment entry. Drug Alcohol Depend 64:165-72
Kwiatkowski, C F; Booth, R E (2001) Methadone maintenance as HIV risk reduction with street-recruited injecting drug users. J Acquir Immune Defic Syndr 26:483-9

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