Both genetic and environmental factors play important roles in the etiology of psychoactive substance use disorders (PSUD). However, our knowledge of the relative importance of these risk factors and how they interrelate in the US population remains limited. We propose a comprehensive, 3-phase twin and twin-family study in the birth-certificate based Virginia Twin Registry (VTR) focusing on 5 substances of abuse: nicotine, caffeine, cannabis, cocaine and stimulants: Phase 1 will consist of analyses of data collected with NIDA support on PSUD in 3,300 personally interviewed unselected female-female, male-male and male-female adult twin pairs from the VTR, with the aim of quantifying the role of genetic, individual-specific environmental and familial-environmental factors in the etiology of substance use, abuse and dependence and clarifying the degree to which these risk factors are similar for different substances and for men and women. In phase 2, we will complete new interviews, focusing on PSUD and its risk factors, with all cooperative members of the male-male twin pairs from this sample (n=2,760) and their parents (n=2,000), measuring twin PSUD on two occasions, utilizing a life history calendar, assessing key risk factor domains from multiple informants and obtaining school and criminal records on all informants. In phase 3, we will examine a series of questions using the complete data set of twins and twins with parents. Analyses to be performed include: i) re-assessing the role of genetic and environmental risk factors in substance use, PSUD, and individual forms of PSUD, using data from multiple occasions and informants, ii) exploring a range of univariate and multi variate twin-family models to clarify the mechanism of the cross-generational transmission of the vulnerability to PSUD, iii) using multi variate twin modeling to clarify the genetic and environmental sources of covariation between substance use and PSUD and psychiatric illness, alcoholism and a range of putative risk factors including temperament, childhood behavioral dysregulation and adolescent peer group deviancy, iv) determining the nature of the interaction between genetic and environmental risk factors for substance use and PSUD and v) developing statistically rigorous, comprehensive etiologic models for PSUD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA011287-01A1
Application #
2628865
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Weinberg, Naimah Z
Project Start
1998-06-15
Project End
2003-05-30
Budget Start
1998-06-15
Budget End
1999-05-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Otowa, Takeshi; York, Timothy P; Gardner, Charles O et al. (2014) The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins. Psychiatry Res 220:404-9
Hsu, Kean J; Young-Wolff, Kelly C; Kendler, Kenneth S et al. (2014) Neuropsychological deficits in major depression reflect genetic/familial risk more than clinical history: a monozygotic discordant twin-pair study. Psychiatry Res 215:87-94
Hettema, John M; Sun, Cuie; Chen, Xiangning et al. (2013) Genetic association study between RGS2 and anxiety-related phenotypes. Psychiatr Genet 23:92
Kendler, Kenneth S; Myers, John; Damaj, M Imad et al. (2013) Early smoking onset and risk for subsequent nicotine dependence: a monozygotic co-twin control study. Am J Psychiatry 170:408-13
Hettema, John M; An, Seon-Sook; van den Oord, Edwin J C G et al. (2013) Genetic association between RGS1 and internalizing disorders. Psychiatr Genet 23:56-60
Otowa, Takeshi; Gardner, Charles O; Kendler, Kenneth S et al. (2013) Parenting and risk for mood, anxiety and substance use disorders: a study in population-based male twins. Soc Psychiatry Psychiatr Epidemiol 48:1841-9
Baker, Jessica H; Maes, Hermine H; Kendler, Kenneth S (2012) Shared environmental contributions to substance use. Behav Genet 42:345-53
van Beek, Jenny H D A; Kendler, Kenneth S; de Moor, Marleen H M et al. (2012) Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood. Behav Genet 42:40-56
Gillespie, Nathan A; Lubke, Gitta H; Gardner, Charles O et al. (2012) Two-part random effects growth modeling to identify risks associated with alcohol and cannabis initiation, initial average use and changes in drug consumption in a sample of adult, male twins. Drug Alcohol Depend 123:220-8
Jackson, K J; Chen, Q; Chen, J et al. (2011) Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. Pharmacogenomics J 11:251-7

Showing the most recent 10 out of 83 publications