The long-term objectives of this research are to employ a cognitive neuropsychological model to conceptualize the effects of HIV and drug abuse on the brain and to relate these effects to critical behaviors in HIV-seropositive persons such as high risk sexual and injection practices. Evidence indicates that drug abuse and HIV infection cause dysfunction in overlapping frontal-subcortical brain regions and that careful study of specific cognitive functions mediated by different frontal-subcortical circuits will permit characterization of HIV-related cognitive impairment and its manifestation in persons who abuse drugs. This study will begin to evaluate the question of whether a history of drug abuse in the context of HIV infection will increase vulnerability to HIV-related cognitive deficits, a question with potential diagnostic and therapeutic implications.
The specific aims of this investigation are to compare the performance of HIV-seropositive (HIV+) and HIV- seronegative (HIV-) with a current or past history of drug abuse on measures of decision-making, working memory, and response inhibition, """"""""executive"""""""" functions dependent on the integrity of prefrontal-subcortical pathways and potential mechanisms of HIV- related cognitive dysfunction; to evaluate the relationship between parameters of drug abuse severity to deficits in executive function in HIV+ and HIV - drug users; to evaluate the presence and severity of executive deficits in HIV+ drug users at different stages of HIV disease; and to evaluate the relationships between executive functions and sexual and drug use-related risk behavior. The study will evaluate cognitive function in HIV+ and HIV- drug users employing state of the art computerized measure developed to model specific impairments associated with dysfunction of frontal-subcortical circuits. Data from the proposed study will advance knowledge of cognitive aspects of HIV-1 infection; the practical implications of how cognitive impairment associated with HIV influences behavior, and recent attempts to bridge the gap on how specific cognitive impairment can influence risk behavior

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Special Emphasis Panel (ZDA1 (35))
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Nemeth-Coslett, Rosemarie V
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University of Illinois at Chicago
Schools of Medicine
United States
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Martin, Eileen; Keutmann, M K; Fogel, J S et al. (2018) Verbal and spatial working memory among drug-using HIV-infected men and women. J Neurovirol 24:488-497
Keutmann, Michael K; Gonzalez, Raul; Maki, Pauline M et al. (2017) Sex differences in HIV effects on visual memory among substance-dependent individuals. J Clin Exp Neuropsychol 39:574-586
Fogel, J; Rubin, L H; Maki, P et al. (2017) Effects of sex and HIV serostatus on spatial navigational learning and memory among cocaine users. J Neurovirol 23:855-863
Martin, Eileen; Gonzalez, Raul; Vassileva, Jasmin et al. (2016) Sex and HIV serostatus differences in decision making under risk among substance-dependent individuals. J Clin Exp Neuropsychol 38:404-15
Martin, Eileen; Gonzalez, Raul; Vassileva, Jasmin et al. (2015) Delay discounting is greater among drug users seropositive for hepatitis C but not HIV. Neuropsychology 29:926-32
Albert, Steven M; Martin, Eileen M (2014) HIV and the neuropsychology of everyday life. Neurology 82:2046-7
Wilson, Michael J; Martin-Engel, Lindsay; Vassileva, Jasmin et al. (2013) An investigation of the effects of antiretroviral central nervous system penetration effectiveness on procedural learning in HIV+ drug users. J Clin Exp Neuropsychol 35:915-25
Martin, Eileen M; DeHaan, Samantha; Vassileva, Jasmin et al. (2013) Decision making among HIV+ drug using men who have sex with men: a preliminary report from the Chicago Multicenter AIDS Cohort Study. J Clin Exp Neuropsychol 35:573-83
Paxton, Jessica L; Vassileva, Jasmin; Gonzalez, Raul et al. (2012) Neurocognitive performance in drug-dependent males and females with posttraumatic stress disorder symptoms. J Clin Exp Neuropsychol 34:521-30
Liu, Richard T; Vassileva, Jasmin; Gonzalez, Raul et al. (2012) A comparison of delay discounting among substance users with and without suicide attempt history. Psychol Addict Behav 26:980-5

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