An estimated 21 percent of the nation's 7.5 million full-time college students have used an illicit drug in the past month. Moreover, our work over the past three years has documented that concurrent nonmedical prescription drug use, other illicit drug use, and heavy drinking can all potentially affect the health, safety and well-being of college students. Unfortunately, most prior research on college students has focused solely on alcohol;the few studies on college student drug use and associated problems have had limited explanatory power or have not covered a wide scope of risk factors and consequences. Questions regarding the persistence of drug problems, (including substance use disorder) and their sequelae after college remain unanswered. This knowledge gap has severely hampered drug prevention efforts and preventive health care services for young adults. In 2003, our investigative team began an unprecedented NIDA- funded initiative to address this gap-and learn more about the natural history and consequences of illicit drug use among college students. Systematic sampling yielded a cohort of 1253 students for a longitudinal prospective study, of which 95 percent are still active in the study after 3 years of follow-up. In-depth annual interviews have yielded a rich dataset containing a wide array risk factors and outcomes. All students, regardless of academic status, are still being studied. This renewal application builds on our previous findings and proposes to continue our follow-up of this valuable cohort to answer new questions about psychosocial and physical health outcomes as they transition to adulthood. Specifically, it aims to: 1) study the persistence of drug use trajectories, including the resolution of drug problems and development of dependence;2) understand how college drug use might interfere with achieving developmental milestones such as occupational goals and adaptive social support structures;3) examine the reciprocal relationships over time of drug use and mental health in relation to physical health (including high-risk sexual behaviors) and quality of life;and, 4) examine potential adverse long-term consequences of cocaine and nonmedical prescription drug use, which have both significantly increased over time in our sample. This renewal offers the field a rare opportunity to probe into new transdisciplinary areas of research, and will use prospective multidimensional modeling that will take advantage of ten years of data to understand their health and functioning in the post-college period. The continuation of this study will maximize the return on NIDA's earlier investment in the project. Ultimately, the results will lead to innovative drug abuse intervention strategies, shape clinical decision-making, and improve health service delivery systems for young adults. Our ambitious and comprehensive approach ensures that this longitudinal prospective study will answer major questions about how to reduce the long-term personal and family turmoil associated with drug abuse, enable young adults to fulfill their individual potential, and reduce unnecessary economic costs to society.

Public Health Relevance

This renewal application to continue following a longitudinal cohort of 1253 college students has broad public health implications in that it focuses on three of the most significant health outcomes affecting young adults (i.e., drug abuse, mental disorders, and sexually transmitted diseases). The project will continue to measure a wide array of risk and protective factors, and is informed by a longitudinal developmental perspective;therefore, it has great potential for elucidating targets for drug abuse prevention in particular, and the delivery of health care services in general for young adults. Our ambitious and comprehensive approach will enable us to identify points at which problematic trajectories can be changed to avoid long-term consequences, enable young adults to fulfill their individual potential, and reduce unnecessary economic costs to society.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Obrien, Moira
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University of Maryland College Park
Organized Research Units
College Park
United States
Zip Code
Arria, Amelia M; Geisner, Irene M; Cimini, M Dolores et al. (2018) Perceived academic benefit is associated with nonmedical prescription stimulant use among college students. Addict Behav 76:27-33
Arria, Amelia M; Jernigan, David H (2018) Addressing College Drinking as a Statewide Public Health Problem: Key Findings From the Maryland Collaborative. Health Promot Pract 19:303-313
Ross, Melissa M; Arria, Amelia M; Brown, Jessica P et al. (2018) College students' perceived benefit-to-risk tradeoffs for nonmedical use of prescription stimulants: Implications for intervention designs. Addict Behav 79:45-51
Payne-Sturges, Devon C; Tjaden, Allison; Caldeira, Kimberly M et al. (2018) Student Hunger on Campus: Food Insecurity Among College Students and Implications for Academic Institutions. Am J Health Promot 32:349-354
Morioka, Christine K; Howard, Donna E; Caldeira, Kimberly M et al. (2018) Affective dysregulation predicts incident nonmedical prescription analgesic use among college students. Addict Behav 76:328-334
Caldeira, Kimberly M; Arria, Amelia M; Allen, Hannah K et al. (2017) Continuity of drunk and drugged driving behaviors four years post-college. Drug Alcohol Depend 180:332-339
Arria, Amelia M; Caldeira, Kimberly M; Vincent, Kathryn B et al. (2017) Do college students improve their grades by using prescription stimulants nonmedically? Addict Behav 65:245-249
Arria, Amelia M; Caldeira, Kimberly M; Bugbee, Brittany A et al. (2017) Trajectories of energy drink consumption and subsequent drug use during young adulthood. Drug Alcohol Depend 179:424-432
Allen, Hannah K; Caldeira, Kimberly M; Bugbee, Brittany A et al. (2017) Drug involvement during and after college: Estimates of opportunity and use given opportunity. Drug Alcohol Depend 174:150-157
Caldeira, Kimberly M; Arria, Amelia M; O'Grady, Kevin E et al. (2017) Risk factors for gambling and substance use among recent college students. Drug Alcohol Depend 179:280-290

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