Support is requested for the continuation of human temporal bone histopathology studies of 1) congenital anomalies, 2) Meniere's disease, 3) sudden hearing loss, 4) facial palsy, and 5) other problems of the ear. In addition to the classic histopathological process and studies, these studies employ unique computer three-dimensional (3-D) reconstruction and measurement methods and special specimen removal technique which has provided unique large, specimens (temporal bones and infratemporal fossa structures). These techniques permit the study of 3-D anatomy, embryology, phylogeny, and pathology of the inner and middle ears and infratemporal fossa structures. In our laboratory more than 1700 temporal bone specimens are either available for study or are being processed. Approximately 165 of our specimens include the infratemporal fossa structures. Only a few other laboratories in the United States have such large collections and no other laboratory has specimens with the infratemporal fossa structures, which we have found invaluable in gaining new information about the anatomy and pathology of the human ear. Furthermore, approximately 25 temporal bone-infratemporal fossa specimens will be added per year; appropriate cases will also be utilized in the proposed studies. An increased understanding of the anatomy and pathology of the human temporal bone and its surrounding structures forms the foundation for improved understanding of clinical problems in otology, audiology, genetics and neurology. Such understanding is essential to better patient care. In order to expand our knowledge, however, we must continue to collect and to examine specimens that include the infratemporal fossa structures and that have been processed for three-dimensional reconstruction and measurement.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Hearing Research Study Section (HAR)
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Eye and Ear Institute of Pittsburgh
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Orita, Yorihisa; Sando, Isamu; Miura, Makoto et al. (2003) Postnatal changes in the connective tissue in the region lateral to the eustachian tube: possible relationship to tube function. Ann Otol Rhinol Laryngol 112:716-21
Hasebe, Seishi; Sando, Isamu; Orita, Yorihisa (2003) Proximity of carotid canal wall to tympanic membrane: a human temporal bone study. Laryngoscope 113:802-7
Orita, Yorihisa; Sando, Isamu; Hasebe, Seishi et al. (2003) Postnatal change on the location of Ostmann's fatty tissue in the region lateral to Eustachian tube. Int J Pediatr Otorhinolaryngol 67:1105-12
Miura, Makoto; Sando, Isamu; Orita, Yorihisa et al. (2002) Histopathologic study of the temporal bones and Eustachian tubes of children with cholesterol granuloma. Ann Otol Rhinol Laryngol 111:609-15
Orita, Yorihisa; Sando, Isamu; Miura, Makoto et al. (2002) Cochleosaccular pathology after perinatal and postnatal asphyxia: histopathologic findings. Otol Neurotol 23:34-8
Haginomori, Shin-ichi; Balaban, Carey D; Miura, Makoto et al. (2002) Cellular proliferation of mucosa-associated lymphoid tissue with otitis media: a preliminary study. Ann Otol Rhinol Laryngol 111:926-32
Haginomori, Shin-Ichi; Sando, Isamu; Miura, Makoto et al. (2002) Temporal bone histopathology in CHARGE association. Ann Otol Rhinol Laryngol 111:397-401
Ishijima, Ken; Sando, Isamu; Miura, Makoto et al. (2002) Postnatal development of static volume of the eustachian tube lumen. A computer-aided three-dimensional reconstruction and measurement study. Ann Otol Rhinol Laryngol 111:832-5
Miura, Makoto; Sando, Isamu; Balaban, Carey D et al. (2002) Estimated locations of the narrowest portion of the eustachian tube lumen during closed and open states. Ann Otol Rhinol Laryngol 111:255-60
Takasaki, Kenji; Sando, Isamu; Balaban, Carey D et al. (2002) Functional anatomy of the tensor veli palatini muscle and Ostmann's fatty tissue. Ann Otol Rhinol Laryngol 111:1045-9

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