Abstract

Proposed studies have three components. The first is to continue the study of the efferent innervation of hair cells, supporting cells and spiral ganglion at the light and ultrastructural levels, characterizing neurotransmitters, efferent density and synaptology. These are following up and extending exciting findings during the current grant period which showed dendro-dendritic synapses in the outer spiral bundle, reciprocal synapses on outer hair cells, innervation of supporting cells and innervation of spiral ganglion cells. The second component is to confirm human findings and characterize the efferent types, using the guinea pig as a model where different efferent lesions can be made. The third component is an in depth examination of the co-pathology and hearing loss associated with the basilar membrane thickening in the human cochlea that they have observed with aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000152-20
Application #
6124946
Study Section
Hearing Research Study Section (HAR)
Program Officer
Freeman, Nancy
Project Start
1979-12-01
Project End
2001-06-30
Budget Start
1999-12-01
Budget End
2001-06-30
Support Year
20
Fiscal Year
2000
Total Cost
$205,019
Indirect Cost

  Institution

Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114

  Publications

Trakimas, Danielle R; Kozin, Elliott D; Ghanad, Iman et al. (2018) Human Otopathologic Findings in Cases of Folded Cochlear Implant Electrodes. Otol Neurotol 39:970-978
Kamakura, Takefumi; O'Malley, Jennifer T; Nadol Jr, Joseph B (2018) Preservation of Cells of the Organ of Corti and Innervating Dendritic Processes Following Cochlear Implantation in the Human: An Immunohistochemical Study. Otol Neurotol 39:284-293
O'Malley, Jennifer T; Burgess, Barbara J; Galler, Donald et al. (2017) Foreign Body Response to Silicone in Cochlear Implant Electrodes in the Human. Otol Neurotol 38:970-977
Kamakura, Takefumi; Lee, Daniel J; Herrmann, Barbara S et al. (2017) Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation. Audiol Neurootol 22:116-123
Ishai, Reuven; Herrmann, Barbara S; Nadol Jr, Joseph B et al. (2017) The pattern and degree of capsular fibrous sheaths surrounding cochlear electrode arrays. Hear Res 348:44-53
Kamakura, Takefumi; Nadol Jr, Joseph B (2016) Correlation between word recognition score and intracochlear new bone and fibrous tissue after cochlear implantation in the human. Hear Res 339:132-41
Kamakura, Takefumi; Nadol Jr, Joseph B (2016) Cochlear Histopathology as Observed in Two Patients With a Cochlear Implant Electrode With Positioner. Otol Neurotol 37:642-6
Burgess, Barbara J; O'Malley, Jennifer T; Kamakura, Takefumi et al. (2016) Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9). Audiol Neurootol 21:88-97
Quesnel, Alicia M; Nakajima, Hideko Heidi; Rosowski, John J et al. (2016) Delayed loss of hearing after hearing preservation cochlear implantation: Human temporal bone pathology and implications for etiology. Hear Res 333:225-234
Nadol Jr, Joseph B; Handzel, Ophir; Amr, Sami (2015) Histopathology of the Human Inner Ear in a Patient With Sensorineural Hearing Loss Caused by a Variant in DFNA5. Otol Neurotol 36:1616-21

Showing the most recent 10 out of 45 publications