Acquired aphasia is language loss resulting from stroke or other brain insult. It is a chronic disability that affects more than one million adult Americans, robbing each of the ability to express his or her language competence. The heterogeneous presentation of aphasia poses a challenge for diagnosis, measurement, and treatment of this devastating condition. This long-running grant endeavors to explain the many faces of aphasia from a theoretical perspective. Its methods and models have spawned new forms of assessing and treating aphasia, and offshoot grants supporting clinical trials and rehabilitation research infrastructure. Continuing goals of this project are to explain aphasic impairments in terms of psycholinguistic processing models, and to refine such models through the use of computational methods. This proposal adds a new goal: to further the understanding of brain-language relationships by combining the psycholinguistic description of production impairments with state-of-the art lesion-analysis methods. The proposal is presented in 2 parts. Part 1 advances the understanding of single-word production impairments using data and models developed in past work. Products developed in Part 1 will facilitate clinicians'and researchers'access to our methods and data. Part 2 focuses on the regulation of competitive word selection, and how impairment in such regulation contributes to the sentence-production impairments in agrammatism and other aphasia presentations. Studies in Part 2 address alternative models of competitive word selection and the putative role of one particular brain region - the left inferior frontal gyrus.
Specific aims for Parts 1 and 2 are framed in terms of anticipated psycholinguistic, anatomical, and computational advances. If successful, this project will advance the understanding of how damage to specific brain networks disrupts the stages and processes of word retrieval and the regulation of sequential word selection. This research is relevant to the diagnosis of acquired disorders of language, the mapping of language functions in the human brain, and the development of theoretically motivated rehabilitation strategies.
| Mirman, Daniel; Landrigan, Jon-Frederick; Kokolis, Spiro et al. (2018) Corrections for multiple comparisons in voxel-based lesion-symptom mapping. Neuropsychologia 115:112-123 |
| Thye, Melissa; Mirman, Daniel (2018) Relative contributions of lesion location and lesion size to predictions of varied language deficits in post-stroke aphasia. Neuroimage Clin 20:1129-1138 |
| Schuchard, Julia; Middleton, Erica L; Schwartz, Myrna F (2017) The timing of spontaneous detection and repair of naming errors in aphasia. Cortex 93:79-91 |
| Pustina, Dorian; Coslett, Harry Branch; Ungar, Lyle et al. (2017) Enhanced estimations of post-stroke aphasia severity using stacked multimodal predictions. Hum Brain Mapp 38:5603-5615 |
| Schwartz, Myrna F; Middleton, Erica L; Brecher, Adelyn et al. (2016) Does naming accuracy improve through self-monitoring of errors? Neuropsychologia 84:272-81 |
| Pustina, Dorian; Coslett, H Branch; Turkeltaub, Peter E et al. (2016) Automated segmentation of chronic stroke lesions using LINDA: Lesion identification with neighborhood data analysis. Hum Brain Mapp 37:1405-21 |
| Kittredge, Audrey K; Dell, Gary S (2016) Learning to speak by listening: Transfer of phonotactics from perception to production. J Mem Lang 89:8-22 |
| Middleton, Erica L; Schwartz, Myrna F; Rawson, Katherine A et al. (2016) Towards a Theory of Learning for Naming Rehabilitation: Retrieval Practice and Spacing Effects. J Speech Lang Hear Res 59:1111-1122 |
| Middleton, Erica L; Schwartz, Myrna F; Rawson, Katherine A et al. (2015) Test-enhanced learning versus errorless learning in aphasia rehabilitation: testing competing psychological principles. J Exp Psychol Learn Mem Cogn 41:1253-61 |
| Middleton, Erica L; Chen, Qi; Verkuilen, Jay (2015) Friends and foes in the lexicon: homophone naming in aphasia. J Exp Psychol Learn Mem Cogn 41:77-94 |
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