Abstract

Studies on the current concepts of adaptive postural control mechanisms will continue by comparing sensorimotor function of normal subjects matched with well defined vestibular deficient subjects. The main goal of the proposed research project is to determine quantitative relationships between direct vestibular sensorimotor reflex control of posture and the role of CNS compensatory mechanisms in patients with vestibular deficits. Studies will be performed using controlled moveable support surface and visual surrounds to alter sensory references while recording sway and electromyographic muscle responses from standing humans. The long term goal is to understand the mechanisms of vestibular dependent sensorimotor interactions in normal and vestibular deficient subjects. Clinical benefits include new diagnostic methods for evaluation of patients with spatial disorientation, and abnormal control of upright posture.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
3R01DC000205-11S1
Application #
3216106
Study Section
Sensory Disorders and Language Study Section (CMS)
Project Start
1982-07-01
Project End
1994-06-30
Budget Start
1992-04-01
Budget End
1994-06-30
Support Year
11
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Good Samaritan Hosp & Medical Center(Prtlnd,OR)
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97210

  Publications

Serrador, Jorge M; Lipsitz, Lewis A; Gopalakrishnan, Gosala S et al. (2009) Loss of otolith function with age is associated with increased postural sway measures. Neurosci Lett 465:10-5
Serrador, Jorge M; Schlegel, Todd T; Black, F Owen et al. (2009) Vestibular effects on cerebral blood flow. BMC Neurosci 10:119
Black, F O; Gianna-Poulin, C; Pesznecker, S C (2001) Recovery from vestibular ototoxicity. Otol Neurotol 22:662-71
Wade, S W; Halmagyi, G M; Black, F O et al. (1999) Time constant of nystagmus slow-phase velocity to yaw-axis rotation as a function of the severity of unilateral caloric paresis. Am J Otol 20:471-8
Black, F O; Paloski, W H; Reschke, M F et al. (1999) Disruption of postural readaptation by inertial stimuli following space flight. J Vestib Res 9:369-78
Merfeld, D M; Black, F O; Wade, S (1998) Clinical use of three-dimensional video measurements of eye movements. Otolaryngol Head Neck Surg 118:S35-8
Black, F O; Paloski, W H (1998) Computerized dynamic posturography: What have we learned from space? Otolaryngol Head Neck Surg 118:S45-51
Black, F O; Wade, S W; Nashner, L M (1996) What is the minimal vestibular function required for compensation? Am J Otol 17:401-9
Black, F O; Brackmann, D E; Hitselberger, W E et al. (1995) Preservation of auditory and vestibular function after surgical removal of bilateral vestibular schwannomas in a patient with neurofibromatosis type 2. Am J Otol 16:431-43
Black, F O; Pesznecker, S; Norton, T et al. (1992) Surgical management of perilymphatic fistulas: a Portland experience. Am J Otol 13:254-62

Showing the most recent 10 out of 11 publications