Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000273-08
Application #
3216383
Study Section
Hearing Research Study Section (HAR)
Project Start
1984-02-01
Project End
1991-07-31
Budget Start
1991-04-01
Budget End
1991-07-31
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Santos-Sacchi, Joseph; Tan, Winston (2018) The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. J Neurosci 38:5495-5506
Tan, Winston J T; Song, Lei; Graham, Morven et al. (2017) Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxid Redox Signal 27:489-509
Song, Lei; Santos-Sacchi, Joseph (2016) A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair Cells. Methods Mol Biol 1427:501-12
Santos-Sacchi, Joseph; Song, Lei (2016) Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5. Biophys J 110:2551-2561
McKay, Sharen E; Yan, Wayne; Nouws, Jessica et al. (2015) Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness. Am J Pathol 185:3132-40
Santos-Sacchi, Joseph; Song, Lei (2014) Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein. Biophys J 107:126-33
Santos-Sacchi, Joseph; Song, Lei (2014) Chloride and salicylate influence prestin-dependent specific membrane capacitance: support for the area motor model. J Biol Chem 289:10823-30
Ricci, Anthony J; Bai, Jun-Ping; Song, Lei et al. (2013) Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish. J Neurosci 33:3131-4
Song, Lei; Santos-Sacchi, Joseph (2013) Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5. Proc Natl Acad Sci U S A 110:3883-8
Okunade, Oluwarotimi; Santos-Sacchi, Joseph (2013) IR laser-induced perturbations of the voltage-dependent solute carrier protein SLC26a5. Biophys J 105:1822-8

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