The broad goals of this research are to identify and delineate the processes and mechanisms and the neural substrates underlying speaking and understanding by investigating speech and language processing deficits in aphasic patients. The major focus of research is on sound structure and the lexicon and the processing stages that map sound to meaning and meaning to sound. With respect to the processing stages that map sound to meaning, it is hypothesized that the deficits of aphasic patients stem from the extent to which sound structure elicits activation in the lexicon. Two potential sources of such impairment will be investigate, one focusing on activation patterns within the lexicon itself and the other on the mapping from sound structure to lexical form. The influence of lexical competition on lexical processing will be investigated by exploring the effects of phonetic category 'goodness' and its influence on the activation of its lexical competitor, the effects of lexical density and frequency on lexical decision latencies, and rhyme and cohort effects on the time course of spoken word recognition. The mapping from sound structure to the lexicon will be investigated by exploring the influence of various changes to the acoustic input on lexical access including the influence of acoustic distortion and indexical features such as voice pitch and speaker. Various methods will be used including lexical decision, semantic priming, discrimination, and eye tracking. With respect to the processes and mechanisms contributing to speech production, it is hypothesized that the speech output deficits of anterior aphasics including Broca's aphasics have as their basis impairments in articulatory implementation. To further map out the nature of this impairment, three hypotheses will be tested: 1. It is proposed that deficits will emerge in the production of those sound segments that require the complex integration of articulatory movements over short periods of time. The production of manner of articulation including stops, affricates, fricatives, and glides will be investigated; 2. It is proposed that deficits in coarticulation will emerge in larger and more complex linguistic contexts, specifically across word boundaries. The influence of vowel coarticulation on a preceding consonant and consonant articulation on a preceding vowel will be explored; 3. It isproposed that phonemic paraphasias, i.e. sound substitutionerrors, produced by anterior aphasics have a phonetic orarticulatory basis. In all of these production studies,acoustic analyses are conducted of speech productions ofboth anterior and posterior aphasic patients to infer thearticulatory states giving rise to the acoustic patterns.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000314-20
Application #
6894643
Study Section
Special Emphasis Panel (ZRG1-BBBP-1 (03))
Program Officer
Cooper, Judith
Project Start
1985-06-01
Project End
2006-11-30
Budget Start
2005-06-01
Budget End
2006-11-30
Support Year
20
Fiscal Year
2005
Total Cost
$245,761
Indirect Cost
Name
Brown University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Luthra, Sahil; Fox, Neal P; Blumstein, Sheila E (2018) Speaker information affects false recognition of unstudied lexical-semantic associates. Atten Percept Psychophys 80:894-912
Ostrand, Rachel; Blumstein, Sheila E; Ferreira, Victor S et al. (2016) What you see isn't always what you get: Auditory word signals trump consciously perceived words in lexical access. Cognition 151:96-107
Kurowski, Kathleen; Blumstein, Sheila E (2016) Phonetic basis of phonemic paraphasias in aphasia: Evidence for cascading activation. Cortex 75:193-203
Theodore, Rachel M; Blumstein, Sheila E; Luthra, Sahil (2015) Attention modulates specificity effects in spoken word recognition: Challenges to the time-course hypothesis. Atten Percept Psychophys 77:1674-84
Blumstein, Sheila E; Amso, Dima (2013) Dynamic Functional Organization of Language: Insights From Functional Neuroimaging. Perspect Psychol Sci 8:44-8
Bullock-Rest, Natasha; Cerny, Alissa; Sweeney, Carol et al. (2013) Neural systems underlying the influence of sound shape properties of the lexicon on spoken word production: do fMRI findings predict effects of lesions in aphasia? Brain Lang 126:159-68
Mirman, Daniel; Yee, Eiling; Blumstein, Sheila E et al. (2011) Theories of spoken word recognition deficits in aphasia: evidence from eye-tracking and computational modeling. Brain Lang 117:53-68
Apfelbaum, Keith S; Blumstein, Sheila E; McMurray, Bob (2011) Semantic priming is affected by real-time phonological competition: evidence for continuous cascading systems. Psychon Bull Rev 18:141-9
Myung, Jong-yoon; Blumstein, Sheila E; Yee, Eiling et al. (2010) Impaired access to manipulation features in Apraxia: evidence from eyetracking and semantic judgment tasks. Brain Lang 112:101-12
Blumstein, Sheila E (2009) Auditory word recognition: evidence from aphasia and functional neuroimaging. Lang Linguist Compass 3:824-838

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