Abstract

""""""""Pheripheral Mechanisms of Hearing"""""""" is a proposal to establish the relationship between the vibrations of the basilar membrane of the mammalian inner ear and their neural correlates, the trains of action potentials that travel along the axons of the cochlear nerve. Thus, this proposal seeks to specify the framework upon which cochlear transduction (the conversion of mechanical signals into neural, electrical all-or-none events) takes place. The general strategy consists of parallel measurements using identical stimuli, of the vibrational response of the basilar membrane and of the electrical activity of single cochlear fibers in the chinchilla. The basilar membrane vibration will be measured by means of an application of the Mossbauer effect that permits detection of very low velocity (e.g., 0.03 mm/sec.) Results of the proposed investigation will be of value in specifying the framework of normal mechanical-to-neural transduction in the human ear (which is not too dissimilar from its chinchilla counterpart). Results will be also of value in specifying possible mechanical aspects of pathology in human deafness.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000419-05
Application #
3216841
Study Section
Hearing Research Study Section (HAR)
Project Start
1987-07-01
Project End
1992-08-31
Budget Start
1991-07-01
Budget End
1992-08-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Charaziak, Karolina K; Siegel, Jonathan H; Shera, Christopher A (2018) Spectral Ripples in Round-Window Cochlear Microphonics: Evidence for Multiple Generation Mechanisms. J Assoc Res Otolaryngol 19:401-419
Temchin, Andrei N; Ruggero, Mario A (2014) Spatial irregularities of sensitivity along the organ of Corti of the cochlea. J Neurosci 34:11349-54
Recio-Spinoso, Alberto; Fan, Yun-Hui; Ruggero, Mario A (2011) Basilar-membrane responses to broadband noise modeled using linear filters with rational transfer functions. IEEE Trans Biomed Eng 58:1456-65
Temchin, Andrei N; Recio-Spinoso, Alberto; Ruggero, Mario A (2011) Timing of cochlear responses inferred from frequency-threshold tuning curves of auditory-nerve fibers. Hear Res 272:178-86
Temchin, Andrei N; Ruggero, Mario A (2010) Phase-locked responses to tones of chinchilla auditory nerve fibers: implications for apical cochlear mechanics. J Assoc Res Otolaryngol 11:297-318
Recio-Spinoso, Alberto; Narayan, Shyamla S; Ruggero, Mario A (2009) Basilar membrane responses to noise at a basal site of the chinchilla cochlea: quasi-linear filtering. J Assoc Res Otolaryngol 10:471-84
Ruggero, Mario A; Temchin, Andrei N (2007) Similarity of traveling-wave delays in the hearing organs of humans and other tetrapods. J Assoc Res Otolaryngol 8:153-66
Temchin, Andrei N; Recio-Spinoso, Alberto; van Dijk, Pim et al. (2005) Wiener kernels of chinchilla auditory-nerve fibers: verification using responses to tones, clicks, and noise and comparison with basilar-membrane vibrations. J Neurophysiol 93:3635-48
Siegel, Jonathan H; Cerka, Amanda J; Recio-Spinoso, Alberto et al. (2005) Delays of stimulus-frequency otoacoustic emissions and cochlear vibrations contradict the theory of coherent reflection filtering. J Acoust Soc Am 118:2434-43
Ruggero, Mario A; Temchin, Andrei N (2005) Unexceptional sharpness of frequency tuning in the human cochlea. Proc Natl Acad Sci U S A 102:18614-9

Showing the most recent 10 out of 23 publications