Distortion-product emissions (DPEs) have been shown to be sensitive indicators of cochlear function. Several features of these particular otacoustic emissions make them important candidates for the measurement of progressive hearing loss. Thus, DPEs appear to uniquely test outer hair-cell function, they are simply measured by inserting a miniature microphone system into the external ear canal, and they can precisely measure the ear's response to subtle gradations in stimulus frequency and intensity. All these positive features suggest that DPEs may someday become a powerful test of hearing impairment. The outcome of a small pilot study we recently completed on both normally hearing and hearing-impaired ears supports the potential utility of DPEs in a clinical setting. The present study proposes first to extend our initial data base to include a larger sampling of normal hearing subjects so that reliable descriptive statistical analyses can be performed. Sources of individual variability in """"""""normal"""""""" ears will be investigated by relating DPEs to other emission types and fine- resolution measures of hearing. In addition, statistical and technical procedures will be investigated to assess their effectiveness in reducing variability in DPE measures and related noise floors in order to increase the dynamic range of the response measure. Secondly, patient populations representing several common progressive-hearing disorders will be tested for DPEs in order to relate these measures to the frequency pattern and degree of hearing loss. An attempt will also be made to determine if the etiology of the hearing disorder significantly influences the DPE results. Finally, selected patients will be monitored over the requested 5-yr project period to establish the ability of DPEs to describe the course of their progressive-hearing losses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000613-05
Application #
3217224
Study Section
Sensory Disorders and Language Study Section (CMS)
Project Start
1989-04-01
Project End
1994-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Martin, Glen K; Stagner, Barden B; Dong, Wei et al. (2016) Comparing Distortion Product Otoacoustic Emissions to Intracochlear Distortion Products Inferred from a Noninvasive Assay. J Assoc Res Otolaryngol 17:271-87
Luebke, Anne E; Stagner, Barden B; Martin, Glen K et al. (2015) Influence of sound-conditioning on noise-induced susceptibility of distortion-product otoacoustic emissions. J Acoust Soc Am 138:58-64
Luebke, Anne E; Stagner, Barden B; Martin, Glen K et al. (2014) Adaptation of distortion product otoacoustic emissions predicts susceptibility to acoustic over-exposure in alert rabbits. J Acoust Soc Am 135:1941-9
Martin, Glen K; Stagner, Barden B; Lonsbury-Martin, Brenda L (2013) Time-domain demonstration of distributed distortion-product otoacoustic emission components. J Acoust Soc Am 134:342-55
Gratton, Michael Anne; Eleftheriadou, Anna; Garcia, Jerel et al. (2011) Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage. Hear Res 277:211-26
Martin, Glen K; Stagner, Barden B; Chung, You Sun et al. (2011) Characterizing distortion-product otoacoustic emission components across four species. J Acoust Soc Am 129:3090-103
Martin, Glen K; Stagner, Barden B; Lonsbury-Martin, Brenda L (2010) Evidence for basal distortion-product otoacoustic emission components. J Acoust Soc Am 127:2955-72
Martin, Glen K; Stagner, Barden B; Fahey, Paul F et al. (2009) Steep and shallow phase gradient distortion product otoacoustic emissions arising basal to the primary tones. J Acoust Soc Am 125:EL85-92
McFadden, Dennis; Martin, Glen K; Stagner, Barden B et al. (2009) Sex differences in distortion-product and transient-evoked otoacoustic emissions compared. J Acoust Soc Am 125:239-46
Fahey, P F; Stagner, B B; Martin, G K (2008) Source of level dependent minima in rabbit distortion product otoacoustic emissions. J Acoust Soc Am 124:3694-707

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