Abstract

The goal of this work is to elucidate the relationship between neural activity in auditory cortex and sound perception. The applicant will determine 1) the abilities of humans and nonhuman primates to perceive and integrate spectral and temporal features of sounds, and 2) the relationship of single neuron responses in auditory cortex to psychophysical performance.
For Aim 1, human and nonhuman subjects will be trained to discriminate sounds that vary along temporal or spectral dimensions, and for Aim 2, neurons will be recorded in nonhuman primate auditory cortex during behavioral discriminations. Signal detection methods will be used to determine the discriminative capabilities of single neurons, and whether their firing is more closely associated with the physical attributes of sound or the higher level decision to respond to the sound. The data will provide information for understanding the effects of cortical disruptions, as well as basic understanding of temporal acoustic processing. The results are of potential use for treating stroke and dyslexia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
3R01DC002514-08S1
Application #
6783215
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Luethke, Lynn E
Project Start
1996-02-01
Project End
2006-01-31
Budget Start
2003-09-01
Budget End
2004-01-31
Support Year
8
Fiscal Year
2003
Total Cost
$49,850
Indirect Cost

  Institution

Name
University of California Davis
Department
Neurosciences
Type
Schools of Arts and Sciences
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Downer, Joshua D; Rapone, Brittany; Verhein, Jessica et al. (2017) Feature-Selective Attention Adaptively Shifts Noise Correlations in Primary Auditory Cortex. J Neurosci 37:5378-5392
Downer, Joshua D; Niwa, Mamiko; Sutter, Mitchell L (2017) Hierarchical differences in population coding within auditory cortex. J Neurophysiol 118:717-731
Downer, Joshua D; Niwa, Mamiko; Sutter, Mitchell L (2015) Task engagement selectively modulates neural correlations in primary auditory cortex. J Neurosci 35:7565-74
Johnson, Jeffrey S; O'Connor, Kevin N; Sutter, Mitchell L (2015) Segregating two simultaneous sounds in elevation using temporal envelope: Human psychophysics and a physiological model. J Acoust Soc Am 138:33-43
Niwa, Mamiko; O'Connor, Kevin N; Engall, Elizabeth et al. (2015) Hierarchical effects of task engagement on amplitude modulation encoding in auditory cortex. J Neurophysiol 113:307-27
Niwa, Mamiko; Johnson, Jeffrey S; O'Connor, Kevin N et al. (2013) Differences between primary auditory cortex and auditory belt related to encoding and choice for AM sounds. J Neurosci 33:8378-95
Johnson, Jeffrey S; Yin, Pingbo; O'Connor, Kevin N et al. (2012) Ability of primary auditory cortical neurons to detect amplitude modulation with rate and temporal codes: neurometric analysis. J Neurophysiol 107:3325-41
Niwa, Mamiko; Johnson, Jeffrey S; O'Connor, Kevin N et al. (2012) Active engagement improves primary auditory cortical neurons' ability to discriminate temporal modulation. J Neurosci 32:9323-34
Niwa, Mamiko; Johnson, Jeffrey S; O'Connor, Kevin N et al. (2012) Activity related to perceptual judgment and action in primary auditory cortex. J Neurosci 32:3193-210
Yin, Pingbo; Johnson, Jeffrey S; O'Connor, Kevin N et al. (2011) Coding of amplitude modulation in primary auditory cortex. J Neurophysiol 105:582-600

Showing the most recent 10 out of 17 publications