Sensory feedback - sensory activity generated in response to one's own movements - enables us to learn complex athletic and musical skills. Sensory feedback also enables learning of complex social skills, including speech, language and other culturally transmitted behaviors. In addition to sensory feedback, the cultural transmission of behavior depends on sensory experience of a behavioral model afforded by another individual. Despite the central importance of culturally transmitted behaviors to normal human function, how these two types of experience act in the brain to enable behavioral learning remains poorly understood. The overarching aim of this proposal is to use high resolution imaging methods combined with genetic and physiological methods to study how experience of a behavioral model and sensory feedback affect the properties of neural circuits essential to the learning and execution of complex, culturally transmitted motor sequences. The significance of the proposed research to the NIH mission is four fold. First, this research is relevant to understanding how electrical stimulation and genetic methods can be used to manipulate sensory feedback signals important to learned behaviors. Second, this research can improve our understanding of how loss of sensory input affects the function of sensorimotor circuits that control learned behaviors. Third, these studies can inform the design of artificial neural circuits that in the future are likely to provide a therapeutic avenue to restore brain function. Fourth, by examining the effects of instructive experience on sensorimotor circuits in the naive juvenile, these studies can identify features of the developing nervous system that facilitate learning.

Public Health Relevance

The proposed research will blend high resolution neuronal imaging and electrical recording with focal brain stimulation and viral genetic methods to determine how sensory signals are harnessed to learn and maintain complex motor sequences.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Study Section
Sensorimotor Integration Study Section (SMI)
Program Officer
Shekim, Lana O
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Duke University
Schools of Medicine
United States
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Hisey, Erin; Kearney, Matthew Gene; Mooney, Richard (2018) A common neural circuit mechanism for internally guided and externally reinforced forms of motor learning. Nat Neurosci 21:589-597
Roberts, Todd F; Hisey, Erin; Tanaka, Masashi et al. (2017) Identification of a motor-to-auditory pathway important for vocal learning. Nat Neurosci 20:978-986
Kim, Hyojin; Kunz, Portia A; Mooney, Richard et al. (2016) Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. J Neurosci 36:4888-94
Hamaguchi, Kosuke; Tanaka, Masashi; Mooney, Richard (2016) A Distributed Recurrent Network Contributes to Temporally Precise Vocalizations. Neuron 91:680-93
Tanaka, Masashi; Singh Alvarado, Jonnathan; Murugan, Malavika et al. (2016) Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences. Proc Natl Acad Sci U S A 113:E1720-7
Tseng, Wei Chou; Jenkins, Paul M; Tanaka, Masashi et al. (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Proc Natl Acad Sci U S A 112:1214-9
Schneider, David M; Mooney, Richard (2015) Motor-related signals in the auditory system for listening and learning. Curr Opin Neurobiol 33:78-84
Peh, Wendy Y X; Roberts, Todd F; Mooney, Richard (2015) Imaging auditory representations of song and syllables in populations of sensorimotor neurons essential to vocal communication. J Neurosci 35:5589-605
Mooney, Richard (2014) Auditory-vocal mirroring in songbirds. Philos Trans R Soc Lond B Biol Sci 369:20130179
Hamaguchi, Kosuke; Tschida, Katherine A; Yoon, Inho et al. (2014) Auditory synapses to song premotor neurons are gated off during vocalization in zebra finches. Elife 3:e01833

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