Abstract

The proposed studies focus on the contribution of the cochlear-efferent system in the susceptibility to noise and the phenomenon of """"""""sound conditioning."""""""" Several hypotheses are proposed to determine whether the susceptibility of the ear can be experimentally manipulated through sound conditioning, if the cochlear-efferent system is involved in sound conditioning and whether auditory or systemic factors are involved in the process. In addition, the molecular bases of protection from sound-overexposure will be explored. The functional measure employed in the experiment is the 2f1-f2 DPOAE and its alteration by presentation of a pure tone presented to the opposite ear. The change in DPOAE with binaural stimulation is proposed as a measure of """"""""efferent strength,"""""""" which appears to vary among individual animals and humans. Three hypotheses are proposed. In the first, awake rabbits will be used as subjects to determine if the efferent system plays a role in 'sound conditioning', whether the effect is ear-specific and whether other systemic factors are involved. The second hypothesis tests the extent to which """"""""sound conditioning"""""""" is apparent in mice that have varying susceptibility to noise-induced hearing loss. The third hypothesis tests whether susceptibility to hearing loss or the prevention from it is associated with specific molecules in the cochlea.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC003114-21
Application #
6660397
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (03))
Program Officer
Donahue, Amy
Project Start
1996-03-01
Project End
2004-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
21
Fiscal Year
2003
Total Cost
$343,789
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Luebke, Anne E; Stagner, Barden B; Martin, Glen K et al. (2015) Influence of sound-conditioning on noise-induced susceptibility of distortion-product otoacoustic emissions. J Acoust Soc Am 138:58-64
Luebke, Anne E; Stagner, Barden B; Martin, Glen K et al. (2014) Adaptation of distortion product otoacoustic emissions predicts susceptibility to acoustic over-exposure in alert rabbits. J Acoust Soc Am 135:1941-9
Fahey, P F; Stagner, B B; Martin, G K (2008) Source of level dependent minima in rabbit distortion product otoacoustic emissions. J Acoust Soc Am 124:3694-707
Bektas, Devrim; Martin, Glen K; Stagner, Barden B et al. (2008) Noise-induced hearing loss in mice treated with antiretroviral drugs. Hear Res 239:69-78
Martin, Glen K; Vazquez, Ana E; Jimenez, Ana M et al. (2007) Comparison of distortion product otoacoustic emissions in 28 inbred strains of mice. Hear Res 234:59-72
Calderon, Alfredo; Derr, Adam; Stagner, Barden B et al. (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res 221:44-58
Fahey, P F; Stagner, B B; Martin, G K (2006) Mechanism for bandpass frequency characteristic in distortion product otoacoustic emission generation. J Acoust Soc Am 119:991-6
Porter, Christopher A; Martin, Glen K; Stagner, Barden B et al. (2006) Distortion-product otoacoustic emission suppression growth in normal and noise-exposed rabbits. J Acoust Soc Am 120:884-900
Meinke, Deanna K; Stagner, Barden B; Martin, Glen K et al. (2005) Human efferent adaptation of DPOAEs in the L1,L2 space. Hear Res 208:89-100
Candreia, Claudia; Martin, Glen K; Stagner, Barden B et al. (2004) Distortion product otoacoustic emissions show exceptional resistance to noise exposure in MOLF/Ei mice. Hear Res 194:109-17

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