Speech sounds are the most important sounds that humans hear, yet our knowledge of how the complex cortical network of auditory and auditory-related brain regions subserves speech perception is limited. Our overarching goal is to understand where and how speech information is represented within this network. The focus of this proposal is to test directly predictive coding models of speech perception. In predictive coding hypotheses, the brain minimizes the differences between internally generated expectations and sensory observations through an ongoing interaction between sensory and higher-order cortical regions. We use novel combinations of complementary invasive and non-invasive experimental methods to study these brain regions in neurosurgery patients who require placement of chronic intracranial electrodes. These experiments involve combining direct cortical electrophysiological recording methods with non-invasive electroencephalography, electrical stimulation techniques and anatomical and functional neuroimaging methods. We also obtain causal evidence of network functional properties by studying the effects of selectively disrupting the function of specific components of this network. Our investigative strategy makes use of these unique experimental opportunities to overcome long-standing barriers to progress in this research field. We will pursue our goals by testing hypotheses regarding: (1) the locations, functional properties and connectivity patterns of auditory cortical fields and auditory-related cortices of the temporal and frontal lobes that are engaged in speech processing, (2) predictive coding models of speech signaling within this network, and (3) the behavioral consequences and neural signatures of selective disruption of the network. These objectives are pursued by an experienced multidisciplinary group of investigators with expertise encompassing all required clinical and research topic areas. To our knowledge, the resulting data will be the first of its kind to directly demonstrate how speech information is processed at all levels of auditory cortical hierarchy and provide causal evidence of the role of feedback projections on speech information processing within canonical auditory cortex. Detailed characterization of this network will improve our understanding of the pathophysiology of disease states affecting this system and will provide mechanistic insights that are required to inform the design of new treatment strategies.

Public Health Relevance

This research program will elucidate the organization of human brain networks engaged in speech perception using a unique combination of non-invasive and invasive experimental methods. By using direct recordings from the brains of neurosurgical patients, detailed information will be obtained that is not available using conventional non-invasive methods. This information will aid the development of novel approaches to diagnosis, treatment and rehabilitation of patients with a wide range of communication disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
2R01DC004290-21
Application #
9981349
Study Section
Auditory System Study Section (AUD)
Program Officer
King, Kelly Anne
Project Start
2000-08-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
21
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Iowa
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Nourski, Kirill V; Steinschneider, Mitchell; Rhone, Ariane E et al. (2018) Processing of auditory novelty across the cortical hierarchy: An intracranial electrophysiology study. Neuroimage 183:412-424
Nagahama, Yasunori; Kovach, Christopher K; Ciliberto, Michael et al. (2018) Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report. J Neurosurg 129:157-164
Oya, Hiroyuki; Gander, Phillip E; Petkov, Christopher I et al. (2018) Neural phase locking predicts BOLD response in human auditory cortex. Neuroimage 169:286-301
Nourski, Kirill V; Steinschneider, Mitchell; Rhone, Ariane E et al. (2018) Auditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology Study. J Neurosci 38:8441-8452
Kikuchi, Yukiko; Attaheri, Adam; Wilson, Benjamin et al. (2017) Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex. PLoS Biol 15:e2000219
Haun, Andrew M; Oizumi, Masafumi; Kovach, Christopher K et al. (2017) Conscious Perception as Integrated Information Patterns in Human Electrocorticography. eNeuro 4:
Baroni, Fabiano; van Kempen, Jochem; Kawasaki, Hiroto et al. (2017) Intracranial markers of conscious face perception in humans. Neuroimage 162:322-343
Nourski, Kirill V; Banks, Matthew I; Steinschneider, Mitchell et al. (2017) Electrocorticographic delineation of human auditory cortical fields based on effects of propofol anesthesia. Neuroimage 152:78-93
Nourski, Kirill V (2017) Auditory processing in the human cortex: An intracranial electrophysiology perspective. Laryngoscope Investig Otolaryngol 2:147-156
Oya, Hiroyuki; Howard, Matthew A; Magnotta, Vincent A et al. (2017) Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI. J Neurosci Methods 277:101-112

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