Many voice disorders, such as unilateral vocal fold paralysis, bowing, or lesions, involve an increase in effort, suggesting that voice efficiency is adversely impacted. At present, clinical measures of voice efficiency are seldom used, in part because they are difficult to interpret. This is due, in part, to incomplete understanding of how the energy in the subglottal airstream is partitioned into work sustaining vocal fold vibration, an into producing sound, and how this partition is altered by the disorders previously mentioned. In addition, only acoustic efficiency measures have been proposed. Finally, any clinically realizable measures of voice function necessarily involve approximation, due to the limited access to the larynx. The proposed research takes a three-fold approach to improving our fundamental understanding of voice energy utilization and translating these findings to clinically useful measures. First, using a combination of aeroelastic-aeroacoustic theory, computer simulation, and physical model experiments, energy utilization in the voice will be investigated. These investigations will be performed for three cases: normal phonation (symmetrical vocal folds), unilateral vocal fold paralysis (vocal fold stiffness asymmetry), and vocal fold bowing. Second current and novel measures of energy utilization and efficiency will be benchmarked against the physical model and simulation data. Energy measures will include power transfer to the vocal folds, and to the sound field in the vocal tract, as well as both acoustic and vibration efficiency Using the same data, energy utilization and efficiency measures are estimated in two ways: (1) as completely as possible, using the full extent of the available data, and (2) using limited data, as constrained by the limitations of clinically realizable measurement, using appropriate approximations. Finally, the current and current and novel clinical measures will be estimated using data from patients suffering from disorders that reduce efficiency through biomechanical issues. The proposed research promises to significantly improve our understanding of vocal energy utilization for normal and disordered phonation, and to begin translation of this knowledge to clinically realizable metrics of voice function.

Public Health Relevance

This research will address the underlying physics of phonation, focusing on how the energy in the subglottal airstream is partitioned into work to vibrate the vocal folds and produce sound. Research will also benchmark current and novel clinically realizable measures of phonatory energy utilization, and of voice efficiency.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC005642-13
Application #
9552133
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Shekim, Lana O
Project Start
2002-07-01
Project End
2020-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
13
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
Organized Research Units
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Yang, Jubiao; Yu, Feimi; Krane, Michael et al. (2018) The Perfectly Matched Layer absorbing boundary for fluid-structure interactions using the Immersed Finite Element Method. J Fluids Struct 76:135-152
Yang, Jubiao; Wang, Xingshi; Krane, Michael et al. (2017) Fully-coupled aeroelastic simulation with fluid compressibility - For application to vocal fold vibration. Comput Methods Appl Mech Eng 315:584-606
Zhang, Lucy T; Yang, Jubiao (2016) Evaluation of aerodynamic characteristics of a coupled fluid-structure system using generalized Bernoulli's principle: An application to vocal folds vibration. J Coupled Syst Multiscale Dyn 4:241-250
Zhang, Lucy T (2014) Modeling of Soft Tissues Interacting with Fluid (Blood or Air) Using the Immersed Finite Element Method. J Biomed Sci Eng 7:130-145
Wang, Xingshi; Zhang, Lucy T (2013) Modified Immersed Finite Element Method For Fully-Coupled Fluid-Structure Interations. Comput Methods Appl Mech Eng 267:
Krane, Michael H; Barry, Michael; Wei, Timothy (2010) Dynamics of temporal variations in phonatory flow. J Acoust Soc Am 128:372-83
Krane, Michael; Barry, Michael; Wei, Timothy (2007) Unsteady behavior of flow in a scaled-up vocal folds model. J Acoust Soc Am 122:3659-70
Krane, Michael H (2005) Aeroacoustic production of low-frequency unvoiced speech sounds. J Acoust Soc Am 118:410-27