Objectives are to develop scientific information and to advance materials technology in permanent adhesive bonding of protective coatings and composites to both dentin and enamel with a practicable method. Success in these objectives will result in less drilling, loss of tooth structure, and need for injections of local anesthetics. Much needed protective coatings of exposed root surfaces could prevent root decay and provide a quick, durable treatment for hypersensitive dentin. The experimental design is to make systematic comparisons of the effectiveness in adhesive bonding of chemical analogues of the compounds now known to give unprecedented strong bonding: an acidic solution containing NPG (N-phenylglycine) and a solvent solution of PMDM (the reaction product of hydroxyethyl methacrylate and pyromellitic dianhydride). Synthesis and evaluation of analogs that are predicted to function more effectively than NRG and PMDM will be used to test hypotheses relating to the spontaneous polymerization of the monomers by molecular species bound to the substrate surfaces. The model substrates will be human dentin and enamel, and the origination of free radicals by the experimental compounds will be identified using electron paramagnetic resonance spectroscopy. Pulse radiolysis techniques will augment this determination of conditions required for radical generation. Improved and standardized methods will be developed for testing adhesion to dentin and enamel in both tensile and shear stress orientations to allow for more decisive statistical comparisons.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Project (R01)
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Oral Biology and Medicine Subcommittee 1 (OBM)
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American Dental Association Foundation
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Bowen, Rafael L; Schumacher, Gary E; Giuseppetti, Anthony A et al. (2009) Adhesive Bonding to Dentin Improved by Polymerizable Cyclodextrin Derivatives. J Res Natl Inst Stand Technol 114:11-20
Bowen, Rafael L; Carey, Clifton M; Flynn, Kathleen M et al. (2009) Synthesis of Polymerizable Cyclodextrin Derivatives for Use in Adhesion-Promoting Monomer Formulations. J Res Natl Inst Stand Technol 114:1-9
Hussain, Latiff A; Dickens, Sabine H; Bowen, Rafael L (2005) Properties of eight methacrylated beta-cyclodextrin composite formulations. Dent Mater 21:210-6
Hussain, Latiff A; Dickens, Sabine H; Bowen, Rafael L (2005) Shear bond strength of experimental methacrylated beta-cyclodextrin-based formulations. Biomaterials 26:3973-9
Hussain, Latiff A; Dickens, Sabine H; Bowen, Rafael L (2004) Effects of polymerization initiator complexation in methacrylated beta-cyclodextrin formulations. Dent Mater 20:513-21
Miniotis, N J; Bennett, P S; Johnston, A D (1993) Molar efficiency study of chlorinated NPG substitutes in dentin bonding. J Dent Res 72:1045-9
Richards, N D; Eichmiller, F; Dickens, S V et al. (1993) The effect of two initiator/stabilizer concentrations in a metal primer on bond strengths of a composite to a base metal alloy. Dent Mater 9:91-4
Simpson, M D; Horner, J A; Brewer, P D et al. (1992) Effects of aluminum oxalate/glycine pretreatment solutions on dentin permeability. Am J Dent 5:324-8
Farahani, M; Johnston, A D; Bowen, R L (1991) The effect of catalyst structure on the synthesis of a dental restorative monomer. J Dent Res 70:67-71
Webb, R E; Johnston, A D (1991) Dentin-bonding molar efficiency using N-phenylglycine, N-phenyl-beta-alanine, or N-methyl-N-phenylglycine. J Dent Res 70:211-4

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