The long-term goals of the proposed research are: (1) to develop topical treatment procedures which can provide a complete or near complete elimination of both coronal and root surface caries yet do not require continued and/or frequent applications, (2) to develop a reliable in vitro caries test which could reduce the need or cost of clinical trials, and (3) to gain a better understanding of the various physicochemical factors which affect the rates of diffusion of the ions involved in the caries process. The propose research on topical fluoridation will be focused on: (1) improvement of our two-step topical F procedure so that the treatment can increase the permanently bound F content of the tooth to the point that it would be resistant to the level of caries challenge expected in humans, and (2) development of application methods which can effectively deliver the treatment agents to the sites which need the protections against caries the most. In the development of in vitro tests for anticaries treatments by measuring the caries resistance of the treated tooth samples, the following two factors will be given careful consideration: (1) Do the products formed by the treatment withstand the washing action of saliva under normal oral conditions for long periods? and (2) Do the treatment products produce a cariostatic condition in or on the tooth surface rather than a simple physical barrier? A bench scale caries model and a computer simulation of the model will be used to study those factors which my affect caries formation and progression. The results obtained will be used to explore the effects of natural or artificially produced permselectivity of enamel on the rate of lesisn proression in vitro. Our concepts on topical fluoridation of enamel will be applied to studies of the action of F on root surface caries. Differences in the chemical and structural properties of the two tissues will be given careful consideration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE005354-10
Application #
3219368
Study Section
(SSS)
Project Start
1978-07-01
Project End
1989-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
10
Fiscal Year
1987
Total Cost
Indirect Cost
Name
American Dental Association Foundation
Department
Type
DUNS #
789085941
City
Chicago
State
IL
Country
United States
Zip Code
60611
Markovic, M; Takagi, S; Chow, L C et al. (2009) Calcium Fluoride Precipitation and Deposition From 12 mmol/L Fluoride Solutions With Different Calcium Addition Rates. J Res Natl Inst Stand Technol 114:293-301
Vogel, G L; Schumacher, G E; Chow, L C et al. (2008) Ca pre-rinse greatly increases plaque and plaque fluid F. J Dent Res 87:466-9
Chow, L C; Takagi, S; Shern, R J et al. (1994) Effects on whole saliva of chewing gums containing calcium phosphates. J Dent Res 73:26-32
Takagi, S; Chow, L C; Sieck, B A (1992) Deposition of loosely bound and firmly bound fluorides on tooth enamel by an acidic gel containing fluorosilicate and monocalcium phosphate monohydrate. Caries Res 26:321-7
Chow, L C; Takagi, S; Shih, S (1992) Effect of a two-solution fluoride mouthrinse on remineralization of enamel lesions in vitro. J Dent Res 71:443-7
Vogel, G L; Mao, Y; Carey, C M et al. (1992) In vivo fluoride concentrations measured for two hours after a NaF or a novel two-solution rinse. J Dent Res 71:448-52
Eidelman, N; Chow, L C (1991) Effects of pH and calcium on hydrolysis of Na2SiF6 and Na2SnF6. A quasi-constant composition titration study. Caries Res 25:101-7
Chow, L C; Takagi, S (1991) Deposition of fluoride on tooth surfaces by a two-solution mouthrinse in vitro. Caries Res 25:397-401
Takagi, S; Chow, L C; Schreiber, C T (1990) Enhanced root fluoride uptake by monocalcium phosphate monohydrate gels. Caries Res 24:18-22
Sieck, B; Takagi, S; Chow, L C (1990) Assessment of loosely-bound and firmly-bound fluoride uptake by tooth enamel from topically applied fluoride treatments. J Dent Res 69:1261-5

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