Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
2R01DE006014-14A1
Application #
2129287
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1982-08-01
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Boesze-Battaglia, Kathleen; Walker, Lisa P; Dhingra, Anuradha et al. (2017) Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1. Front Cell Infect Microbiol 7:469
Leonard, Stephanie A; Petito, Lucia C; Stephansson, Olof et al. (2017) Weight gain during pregnancy and the black-white disparity in preterm birth. Ann Epidemiol 27:323-328.e1
Scuron, Monika D; Boesze-Battaglia, Kathleen; Dlaki?, Mensur et al. (2016) The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin. Front Cell Infect Microbiol 6:168
Shenker, B J; Walker, L P; Zekavat, A et al. (2016) Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate. Mol Oral Microbiol 31:33-42
Shenker, Bruce J; Boesze-Battaglia, Kathleen; Scuron, Monika Damek et al. (2016) The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity. Cell Microbiol 18:223-43
Boesze-Battaglia, Kathleen; Walker, Lisa P; Zekavat, Ali et al. (2015) The Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Active Subunit CdtB Contains a Cholesterol Recognition Sequence Required for Toxin Binding and Subunit Internalization. Infect Immun 83:4042-55
Shenker, Bruce J; Ojcius, David M; Walker, Lisa P et al. (2015) Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines. Infect Immun 83:1487-96
Shenker, Bruce J; Walker, Lisa P; Zekavat, Ali et al. (2014) Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines. Cell Microbiol 16:1391-404
Shenker, Bruce J; Ali, Hydar; Boesze-Battaglia, Kathleen (2011) PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Curr Pharm Des 17:3815-22
Shenker, Bruce J; Boesze-Battaglia, Kathleen; Zekavat, Ali et al. (2010) Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase. Mol Immunol 48:203-10