The long-range goal of this work is to develop a comprehensive model of mechanical influence on craniofacial growth. As a first step, the current project will characterize postnatal growth and stress/strain relations in a system which is well understood functionally: the masseter-zygomatic arch complex in the pig. Questions to be addressed include: (1) Can bone growth and periosteal stretching account for ontogenetic changes in muscles function? This study will employ radiographic markers for simultaneous monitoring of muscle, periosteum, and bone growth. (2) How do functional strains in the zygomatic arch relate to activity in the masseter? In vivo bone strain will be measured simultaneously with muscle activity while pigs are chewing. (3) Does bond apposition follow the orientation of net or maximum strain? Growth data from (1) will be correlated will strain data from (2) to answer this question. (4) Is the growth of intramuscular tendons determined by muscle force? The growth of the superficial aponeurosis of the masseter will be analyzed quantitatively and correlated with muscle fiber orientation. (5) What are the in vivo strains in intramuscular tendons? Strain will be measured directly with cinefluorography and correlated with anatomical data. Finally, these studies will be generalized to other species to see whether the causal relationships hold true for other mammals (including man), and whether prenatal growth follows the same rules as postnatal growth. This work has direct application to clinical problems related to abnormal biomechanical effects, such as facial deformities and conseqences of orthognatic surgery.
| Al Dayeh, Ayman A; Herring, Susan W (2014) Cellular proliferation in the nasal septal cartilage of juvenile minipigs. J Anat 225:604-13 |
| Al Dayeh, Ayman A; Herring, Susan W (2014) Compressive and tensile mechanical properties of the porcine nasal septum. J Biomech 47:154-61 |
| Al Dayeh, Ayman A; Rafferty, Katherine L; Egbert, Mark et al. (2013) Real-time monitoring of the growth of the nasal septal cartilage and the nasofrontal suture. Am J Orthod Dentofacial Orthop 143:773-83 |
| Herring, Susan W; Rafferty, Katherine L; Liu, Zi Jun et al. (2011) Mastication and the postorbital ligament: dynamic strain in soft tissues. Integr Comp Biol 51:297-306 |
| Ochareon, Pannee; Herring, Susan W (2011) Cell replication in craniofacial periosteum: appositional vs. resorptive sites. J Anat 218:285-97 |
| Dutra, Eliane H; Caria, Paulo H F; Rafferty, Katherine L et al. (2010) The buccinator during mastication: A functional and anatomical evaluation in minipigs. Arch Oral Biol 55:627-38 |
| Burn, A K; Herring, S W; Hubbard, R et al. (2010) Dietary consistency and the midline sutures in growing pigs. Orthod Craniofac Res 13:106-13 |
| Al Dayeh, Ayman A; Rafferty, Katherine L; Egbert, Mark et al. (2009) Deformation of nasal septal cartilage during mastication. J Morphol 270:1209-18 |
| Herring, Susan W (2008) Mechanical influences on suture development and patency. Front Oral Biol 12:41-56 |
| Ochareon, Pannee; Herring, Susan W (2007) Growing the mandible: role of the periosteum and its cells. Anat Rec (Hoboken) 290:1366-76 |
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