Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE008941-08
Application #
2130252
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1989-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Castle, Anna M; Huang, Amy Y; Castle, J David (2002) The minor regulated pathway, a rapid component of salivary secretion, may provide docking/fusion sites for granule exocytosis at the apical surface of acinar cells. J Cell Sci 115:2963-73
Huang, A Y; Castle, A M; Hinton, B T et al. (2001) Resting (basal) secretion of proteins is provided by the minor regulated and constitutive-like pathways and not granule exocytosis in parotid acinar cells. J Biol Chem 276:22296-306
Arvan, P; Castle, D (1998) Sorting and storage during secretory granule biogenesis: looking backward and looking forward. Biochem J 332 ( Pt 3):593-610
Castle, A M; Castle, J D (1998) Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein. Mol Biol Cell 9:575-83
Castle, A M; Huang, A Y; Castle, J D (1998) Immunoglobulin-derived polypeptides enter the regulated secretory pathway in AtT-20 cells. FEBS Lett 439:341-5
Castle, A M; Huang, A Y; Castle, J D (1997) Passive sorting in maturing granules of AtT-20 cells: the entry and exit of salivary amylase and proline-rich protein. J Cell Biol 138:45-54
Castle, J D; Castle, A M (1996) Two regulated secretory pathways for newly synthesized parotid salivary proteins are distinguished by doses of secretagogues. J Cell Sci 109 ( Pt 10):2591-9
Castle, A M; Schwarzbauer, J E; Wright, R L et al. (1995) Differential targeting of recombinant fibronectins in AtT-20 cells based on their efficiency of aggregation. J Cell Sci 108 ( Pt 12):3827-37
Girard, L R; Castle, A M; Hand, A R et al. (1993) Characterization of common salivary protein 1, a product of rat submandibular, sublingual, and parotid glands. J Biol Chem 268:26592-601
Castle, J D; Castle, A M (1993) Sorting and secretion of salivary proteins. Crit Rev Oral Biol Med 4:393-8

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